Fitting Evaluation of Hydrogel and Silicone Hydrogel Sphere Design Contact Lenses

NCT ID: NCT03098745

Last Updated: 2019-04-09

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-02-01

Study Completion Date

2017-04-11

Brief Summary

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The aim of this non-dispensing fitting study is to evaluate the short term lens fit, vision performance of three monthly replacement sphere lenses.

Detailed Description

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This is a 40-subject, double masked, randomized, bilateral, non-dispensing fitting trial comparing hydrogel and silicone hydrogel lens materials. It is anticipated that this study will involve 2 visits for each lens pair, as follows: Visits: V1 (lens dispensing), V2 (1 hour post lens settling). Each subject will be randomized to wear each pair bilaterally in a series of three short fitting comparisons.

Conditions

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Myopia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Omafilcon A

Participants are randomized to wear omafilcon A lens pair bilaterally for 1 hour during the study.

Group Type ACTIVE_COMPARATOR

Omafilcon A

Intervention Type DEVICE

contact lens

Somofilcon A

Participants are randomized to wear somofilcon A lens pair bilaterally for 1 hour during the study.

Group Type ACTIVE_COMPARATOR

Somofilcon A

Intervention Type DEVICE

contact lens

Omafilcon A - Proclear (PC)

Participants are randomized to wear omafilcon A - PC lens pair bilaterally for 1 hour during the study.

Group Type ACTIVE_COMPARATOR

Omafilcon A - Proclear (PC)

Intervention Type DEVICE

contact lens

Interventions

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Omafilcon A

contact lens

Intervention Type DEVICE

Somofilcon A

contact lens

Intervention Type DEVICE

Omafilcon A - Proclear (PC)

contact lens

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* A person is eligible for inclusion in the study if he/she:

* Is between 18 and 40 years of age (inclusive).
* Has had a self-reported visual exam in the last two years.
* Is an adapted soft CL (Contact Lens) wearer who is not wearing any of the study lenses.
* Has a CL spherical prescription between - 1.00 and - 6.00 (inclusive)
* Has a spectacle cylinder up to 0.75D (Diopter) in each eye.
* Can achieve best corrected spectacle distance visual acuity of 20/25 (0.10 logMAR) or better in each eye.
* Can achieve a distance visual acuity of 20/30 (0.18 logMAR) or better in each eye with the study contact lenses.
* Has clear corneas and no active ocular disease.
* Has read, understood and signed the information consent letter.
* Patient contact lens refraction should fit within the available parameters of the study lenses.
* Is willing to comply with the wear schedule.
* Is willing to comply with the visit schedule.

Exclusion Criteria

* A person will be excluded from the study if he/she:

* Has never worn contact lenses before.
* Currently wears rigid gas permeable contact lenses.
* Has a history of not achieving comfortable CL wear (5 days per week; \> 8 hours/day)
* Has a CL prescription outside the range of - 1.00 to - 6.00D
* Has a spectacle cylinder ≥1.00D of cylinder in either eye.
* Has contact lens best corrected distance vision worse than 20/25 (0.10 logMAR) in either eye.
* Presence of clinically significant (grade 2-4) anterior segment abnormalities.
* Presence of ocular or systemic disease or need of medications which might interfere with contact lens wear.
* Slit lamp findings that would contraindicate contact lens wear such as:

* Pathological dry eye or associated findings
* Pterygium, pinguecula, or corneal scars within the visual axis
* Neovascularization \> 0.75 mm in from of the limbus
* Giant papillary conjunctivitis (GCP) worse than grade 1
* Anterior uveitis or iritis (past or present)
* Seborrheic eczema, Seborrheic conjunctivitis
* History of corneal ulcers or fungal infections
* Poor personal hygiene
* Has a known history of corneal hypoesthesia (reduced corneal sensitivity)
* Has aphakia, keratoconus or a highly irregular cornea.
* Has Presbyopia or has dependence on spectacles for near work over the contact lenses.
* Has undergone corneal refractive surgery.
* Is participating in any other type of eye related clinical or research study.
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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CooperVision, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ruben Velázquez Guerrero, MSc., FIACLE

Role: PRINCIPAL_INVESTIGATOR

National Autonomous University, School of Optometry

Locations

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Optometry Clinic, National Autonomous University

Mexico City, , Mexico

Site Status

Countries

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Mexico

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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EX-MKTG-79

Identifier Type: -

Identifier Source: org_study_id

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