Clinical Evaluation of Hydrogels vs Silicone Hydrogel Contact Lenses

NCT ID: NCT01966770

Last Updated: 2020-07-30

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-10-31

Study Completion Date

2013-11-30

Brief Summary

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The aim of this fitting study is to evaluate the clinical performance of different hydrogel and silicone hydrogel contact lenses.

Detailed Description

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This is a 20-subject, double masked, randomized, contra lateral, 2-day non-dispensing fitting trial.

Conditions

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Myopia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Pair 1 (ocufilcon D / ocufilcon D)

Randomized to contra lateral lens pair 1 (ocufilcon D hydrogel / ocufilcon D hydrogel)

Group Type ACTIVE_COMPARATOR

Pair 1 (ocufilcon D / ocufilcon D)

Intervention Type DEVICE

Randomized to contra lateral lens pair 1 (ocufilcon D hydrogel / ocufilcon D hydrogel)

Pair 2 (ocufilcon D / enfilcon A)

Randomized to contra lateral lens pair 2 (ocufilcon D hydrogel / enfilcon A silicone)

Group Type ACTIVE_COMPARATOR

Pair 2 (ocufilcon D / enfilcon A)

Intervention Type DEVICE

Randomized to contra lateral lens pair 2 (ocufilcon D hydrogel / enfilcon A silicone)

Pair 3 (ocufilcon D / comfilcon A)

Randomized to contra lateral lens pair 3 (ocufilcon D hydrogel / comfilcon A silicone)

Group Type ACTIVE_COMPARATOR

Pair 3 (ocufilcon D / comfilcon A)

Intervention Type DEVICE

Randomized to contra lateral lens pair 3 (ocufilcon D hydrogel / comfilcon A silicone)

Pair 4 (methafilcon A / methafilcon A)

Randomized to contra lateral lens pair 4 (methafilcon A hydrogel sphere / methafilcon A hydrogel asphere)

Group Type ACTIVE_COMPARATOR

Pair 4 (methafilcon A / methafilcon A)

Intervention Type DEVICE

Randomized to contra lateral lens pair 4 (methafilcon A hydrogel sphere / methafilcon A hydrogel asphere)

Pair 5 (methafilcon A / comfilcon A)

Randomized to contra lateral lens pair 5 (methafilcon A hydrogel / comfilcon A silicone)

Group Type ACTIVE_COMPARATOR

Pair 5 (methafilcon A / comfilcon A)

Intervention Type DEVICE

Randomized to contra lateral lens pair 5 (methafilcon A hydrogel / comfilcon A silicone)

Pair 6 (omafilcon A / comfilcon A)

Randomized to contra lateral lens pair 6 (omafilcon A hydrogel / comfilcon A silicone)

Group Type ACTIVE_COMPARATOR

Pair 6 (omafilcon A / comfilcon A)

Intervention Type DEVICE

Randomized to contra lateral lens pair 6 (omafilcon A hydrogel / comfilcon A silicone)

Interventions

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Pair 1 (ocufilcon D / ocufilcon D)

Randomized to contra lateral lens pair 1 (ocufilcon D hydrogel / ocufilcon D hydrogel)

Intervention Type DEVICE

Pair 2 (ocufilcon D / enfilcon A)

Randomized to contra lateral lens pair 2 (ocufilcon D hydrogel / enfilcon A silicone)

Intervention Type DEVICE

Pair 3 (ocufilcon D / comfilcon A)

Randomized to contra lateral lens pair 3 (ocufilcon D hydrogel / comfilcon A silicone)

Intervention Type DEVICE

Pair 4 (methafilcon A / methafilcon A)

Randomized to contra lateral lens pair 4 (methafilcon A hydrogel sphere / methafilcon A hydrogel asphere)

Intervention Type DEVICE

Pair 5 (methafilcon A / comfilcon A)

Randomized to contra lateral lens pair 5 (methafilcon A hydrogel / comfilcon A silicone)

Intervention Type DEVICE

Pair 6 (omafilcon A / comfilcon A)

Randomized to contra lateral lens pair 6 (omafilcon A hydrogel / comfilcon A silicone)

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

A person is eligible for inclusion in the study if he/she:

* Is between 18 and 40 years of age (inclusive)
* Has had a self-reported visual exam in the last two years
* Is an adapted soft contact lens wearer
* Has a cl spherical prescription between -1.00 and -6.00 (inclusive)
* Has a spectacle cylinder up to 0.75D (diopter) in each eye
* Is correctable to a visual acuity of 20/25 or better in both eyes
* Has clear corneas and no active ocular disease
* Has read, understood and signed the information consent letter
* Is willing to comply with the wear schedule
* Is willing to comply with the visit schedule

Exclusion Criteria

A person will be excluded from the study if he/she:

* Has never worn contact lenses before
* Currently wears rigid gas permeable contact lenses
* Has a history of not achieving comfortable contact lens wear (5 days per week; \> 8 hours/day)
* Has a contact lens prescription outside the range of -1.00 to -6.00D
* Has a spectacle cylinder ≥ 1.00D of cylinder in either eye
* Has best corrected spectacle distance vision worse than 20/25 in either eye
* Has any systemic or topical medications that will affect ocular health
* Has any ocular pathology or severe insufficiency of lacrimal secretion
* Has persistent, clinically significant corneal or conjunctival staining
* Has active neovascularization or any central corneal scars
* Is aphakic
* Is presbyopic
* Has undergone corneal refractive surgery
* Is participating in any other type of eye related conical or research study
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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CooperVision, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Meng Lin, OD PhD FAAO

Role: PRINCIPAL_INVESTIGATOR

CRC-UC Berkeley

Locations

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University of California, Berkeley Clinical Research Center (UCB-CRC)

Berkeley, California, United States

Site Status

Countries

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United States

Other Identifiers

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EX-MKTG-44

Identifier Type: -

Identifier Source: org_study_id

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