EFECAB: Improving Pig Management to Prevent Epilepsy in Burkina Faso

NCT ID: NCT03095339

Last Updated: 2018-04-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

58 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-02-21

Study Completion Date

2015-01-31

Brief Summary

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This is a pre-post randomized community-based controlled trial aimed at estimating the effectiveness of an educational package developed using PRECEDE PROCEED to reduce the cumulative incidence of Taenia solium cysticercosis in three Provinces of Burkina Faso. The study design included an 18-months baseline study to measure baseline cumulative incidence of cysticercosis followed by an 18-month post randomization study to measure the effectiveness of the intervention. Sixty villages of three Provinces of Burkina Faso were included. The primary outcome was the change in the baseline to post randomization cumulative incidence in the intervention group compared to the control group.

Detailed Description

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Conditions

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Cysticercosis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

This is a pre-post community-based randomized controlled trial. The unit of randomization is the village (community)
Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Educational package

The educational package included the offering of the Self-Esteem , Associative strengths, Resourcefulness, Action-planning and Responsibility (SARAR) Participatory Hygiene and Sanitation Transformation (PHAST) approach, a 52 minutes educational movie and accompanying cartoon booklet. The package was developed using the PRECEDE approach.

Group Type ACTIVE_COMPARATOR

Educational package

Intervention Type OTHER

The educational package was offered to 30 villages post randomization. The field team completed the SARAR PHAST with community members for 2-3 days in each intervention village. The movie was projected every night for 2-3 days in each intervention village.

Control

The control group did not receive any intervention

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Educational package

The educational package was offered to 30 villages post randomization. The field team completed the SARAR PHAST with community members for 2-3 days in each intervention village. The movie was projected every night for 2-3 days in each intervention village.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Population of at least 1000 at the 2006 census
* Present on the map of the "Institut Géographique du Burkina 2000"
* Separated from another village by at least 5 kilometers.


* Aged 5 years old or more
* Has lived in the village for at least 12 months
* Not planning to move in the next three years

Exclusion Criteria

* Village located on a National or Provincial road
* Village located within 20 km of Koudougou or Ouagadougou
* Regional or Provincial Capital
* Absence of pigs in the village

At the individual level, the following eligibility criteria were used:


* Presence of confirmed epilepsy or progressively worsening severe chronic headaches at baseline.
Minimum Eligible Age

5 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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AFRICSanté

OTHER

Sponsor Role collaborator

Institute of Tropical Medicine, Belgium

OTHER

Sponsor Role collaborator

Institut de Recherche en Sciences de la Sante, Burkina Faso

OTHER_GOV

Sponsor Role collaborator

University of Ouagadougou, Burkina Faso

OTHER

Sponsor Role collaborator

University Hospital, Limoges

OTHER

Sponsor Role collaborator

Centre Universitaire Souro Sanou

UNKNOWN

Sponsor Role collaborator

Technical University of Munich

OTHER

Sponsor Role collaborator

Brown University

OTHER

Sponsor Role collaborator

University of Oklahoma

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Hélène Carabin, DVM PhD

Role: PRINCIPAL_INVESTIGATOR

University of Oklahoma

Locations

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AFRICSanté

Bobo-Dioulasso, , Burkina Faso

Site Status

Countries

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Burkina Faso

References

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Carabin H, Traore AA. Taenia solium taeniasis and cysticercosis control and elimination through community-based interventions. Curr Trop Med Rep. 2014 Dec 1;1(4):181-193. doi: 10.1007/s40475-014-0029-4.

Reference Type BACKGROUND
PMID: 25544938 (View on PubMed)

Nitiema P, Carabin H, Hounton S, Praet N, Cowan LD, Ganaba R, Kompaore C, Tarnagda Z, Dorny P, Millogo A, Efecab. Prevalence case-control study of epilepsy in three Burkina Faso villages. Acta Neurol Scand. 2012 Oct;126(4):270-8. doi: 10.1111/j.1600-0404.2011.01639.x. Epub 2012 Jan 31.

Reference Type BACKGROUND
PMID: 22289127 (View on PubMed)

John CC, Carabin H, Montano SM, Bangirana P, Zunt JR, Peterson PK. Global research priorities for infections that affect the nervous system. Nature. 2015 Nov 19;527(7578):S178-86. doi: 10.1038/nature16033.

Reference Type BACKGROUND
PMID: 26580325 (View on PubMed)

Carabin H, Millogo A, Cisse A, Gabriel S, Sahlu I, Dorny P, Bauer C, Tarnagda Z, Cowan LD, Ganaba R. Prevalence of and Factors Associated with Human Cysticercosis in 60 Villages in Three Provinces of Burkina Faso. PLoS Negl Trop Dis. 2015 Nov 20;9(11):e0004248. doi: 10.1371/journal.pntd.0004248. eCollection 2015 Nov.

Reference Type BACKGROUND
PMID: 26588468 (View on PubMed)

Dermauw V, Ganaba R, Cisse A, Ouedraogo B, Millogo A, Tarnagda Z, Van Hul A, Gabriel S, Carabin H, Dorny P. Taenia hydatigena in pigs in Burkina Faso: A cross-sectional abattoir study. Vet Parasitol. 2016 Oct 30;230:9-13. doi: 10.1016/j.vetpar.2016.10.022. Epub 2016 Oct 24.

Reference Type BACKGROUND
PMID: 27884445 (View on PubMed)

Carabin H, Winkler AS, Dorny P. Taenia solium cysticercosis and taeniosis: Achievements from the past 10 years and the way forward. PLoS Negl Trop Dis. 2017 Apr 20;11(4):e0005478. doi: 10.1371/journal.pntd.0005478. eCollection 2017 Apr. No abstract available.

Reference Type BACKGROUND
PMID: 28426664 (View on PubMed)

Ngowi H, Ozbolt I, Millogo A, Dermauw V, Some T, Spicer P, Jervis LL, Ganaba R, Gabriel S, Dorny P, Carabin H. Development of a health education intervention strategy using an implementation research method to control taeniasis and cysticercosis in Burkina Faso. Infect Dis Poverty. 2017 Jun 1;6(1):95. doi: 10.1186/s40249-017-0308-0.

Reference Type RESULT
PMID: 28569208 (View on PubMed)

Sahlu I, Bauer C, Ganaba R, Preux PM, Cowan LD, Dorny P, Millogo A, Carabin H. The impact of imperfect screening tools on measuring the prevalence of epilepsy and headaches in Burkina Faso. PLoS Negl Trop Dis. 2019 Jan 17;13(1):e0007109. doi: 10.1371/journal.pntd.0007109. eCollection 2019 Jan.

Reference Type DERIVED
PMID: 30653519 (View on PubMed)

Provided Documents

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Document Type: Study Protocol

View Document

Related Links

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http://africsante.org/

Website of the facility in Burkina Faso which managed the study

Other Identifiers

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1419

Identifier Type: -

Identifier Source: org_study_id

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