Strategic MAnagement to Optimize Response To Cardiac Resynchronization Therapy Registry

NCT ID: NCT03075215

Last Updated: 2023-10-25

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

2044 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-04-14

Study Completion Date

2021-11-15

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

To learn in a general Cardiac Resynchronization Therapy Defibrillators (CRT-D) population, which optimization techniques are used and how effective they are. It will compare 12-month response rates among different optimization methods and characterize which selected subject subgroups achieve better response than others.

A subset of SMART Registry subjects will contribute to the NG4 Post Market Clinical Follow Up (PMCF) Cohort whose objective is collecting data on the NG4 CRT-D features and device usage in a real world setting and monitor long term safety associated with these devices to support CE Mark.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Heart Failure

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Device Programming of the Boston Scientific Cardiac Resynchronization Therapy Defibrillator (CRT-D)

The optimization during the standard of care visits in the first 12 months following implantation

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Subject implanted or upgraded with a NG3 or NG4 CRT-D device connected with any manufacturer quadripolar LV lead based on BSC labeling for devices in specific geographies.
* Subjects must be enrolled between 1 and 21 calendar days post CRT-D implantation procedure.
* Subject is age 18 or above, or of legal age to give informed consent specific to each country and national laws
* Subject is willing and capable of complying with follow-up visits and procedures as defined by this protocol

Exclusion Criteria

* Subject with documented life expectancy of less than 12 months
* Subject currently on the active heart transplant list or has a current Left Ventricular Assist Device or other assist device (mechanical circulatory support device).
* Subject who have had a pre-existing CRT device
* Subject enrolled in any other concurrent clinical trial without prior written approval from BSC Clinical Trial Manager
* Women of childbearing potential who are or might be pregnant at time of study enrolment
* Any contra-indication to receive a CRT-D device per local guidelines
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Boston Scientific Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Jose-Ignacio Garcia-Bolao, PhD, FESC

Role: PRINCIPAL_INVESTIGATOR

Clinica Universidad de Navarra

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Providence Alaska Medical Center

Anchorage, Alaska, United States

Site Status

CardioVascular Associates of Mesa

Mesa, Arizona, United States

Site Status

Arrhythmia Research Group

Jonesboro, Arkansas, United States

Site Status

Comprehensive Cardiovascular Medical Group

Bakersfield, California, United States

Site Status

VA Loma Linda Healthcare System

Loma Linda, California, United States

Site Status

Western Connecticut Health Network/ Danbury Hospital

Danbury, Connecticut, United States

Site Status

Bay Area Cardiology Associates, P.A.

Brandon, Florida, United States

Site Status

North Florida/South Georgia Veterans Health System

Gainesville, Florida, United States

Site Status

Northeast Georgia Heart Center

Gainesville, Georgia, United States

Site Status

The University of Illinois Medical Center

Chicago, Illinois, United States

Site Status

Riverside Medical Center / Midwest Arrhythmia Consultants

Kankakee, Illinois, United States

Site Status

Ball Memorial Hospital

Muncie, Indiana, United States

Site Status

Midwest Cardiovascular Research Foundation

Davenport, Iowa, United States

Site Status

Cardiovascular Institute of the South

Lafayette, Louisiana, United States

Site Status

Sinai Hospital of Baltimore

Baltimore, Maryland, United States

Site Status

Peninsula Cardiology Associates

Salisbury, Maryland, United States

Site Status

Hurley Medical Center

Flint, Michigan, United States

Site Status

Summit Medical Group, P.A.

Berkeley Heights, New Jersey, United States

Site Status

Trinity Medical WNY,PC

Buffalo, New York, United States

Site Status

Columbia. University Medical Center/ NY Presbyterian Hospital

New York, New York, United States

Site Status

New Hanover Regional Medical Center

Wilmington, North Carolina, United States

Site Status

St. Alexius Medical Center

Bismarck, North Dakota, United States

Site Status

Kettering Medical Center

Kettering, Ohio, United States

Site Status

Abington Memorial Hospital

Abington, Pennsylvania, United States

Site Status

Regional Cardiac Arrythmia

Washington, Pennsylvania, United States

Site Status

Texas Heart Rhythm

Houston, Texas, United States

Site Status

McAllen Medical Heart Hospital

McAllen, Texas, United States

Site Status

Cardiology Clinic of San Antonio

San Antonio, Texas, United States

Site Status

Hunter Holmes McGuire VA Medical Center

Richmond, Virginia, United States

Site Status

Flinders Medical Centre

Bedford Park, South Australia, Australia

Site Status

Monash Medical Centre

Clayton, Victoria, Australia

Site Status

Peninsula Health

Frankston, Victoria, Australia

Site Status

Barwon Health Myers House Ground Floor Geelong Hospital

Geelong, Victoria, Australia

Site Status

The Alfred Hospital

Melbourne, Victoria, Australia

Site Status

Landeskrankenhaus Salzburg Universitätsklinikum der PMU

Salzburg, , Austria

Site Status

Allgemeines Krankenhaus der Stadt Wien, Univ.Klinik für Innere Medizin II

Vienna, , Austria

Site Status

Krankenhaus Nord

Vienna, , Austria

Site Status

Virga Jesse Ziekenhuis

Hasselt, , Belgium

Site Status

UCL de Mont Godinne

Yvoir, , Belgium

Site Status

Sunnybrook Health Sciences Centre

Toronto, Ontario, Canada

Site Status

Fleurimont Hospital (CHU de Sherbrooke)

Sherbrooke, Quebec, Canada

Site Status

Royal Alexandra Hospital - Cardiology Research CK Hui Heart Centre

Edmonton, , Canada

Site Status

Hôpital du Sacré-Cœur de Montréal

Montreal, , Canada

Site Status

Faculty Hospital U sv Anny

Brno, , Czechia

Site Status

Kardiologicke centrum AGEL

Pardubice, , Czechia

Site Status

IKEM - Institut klinicke a experimentalni mediciny

Prague, , Czechia

Site Status

Centre Hospitalier de la Cote Basque

Bayonne, , France

Site Status

CHU de Besancon

Besançon, , France

Site Status

CHU Brest - Hopital Cavale Blanche

Brest, , France

Site Status

Ch de Cannes

Cannes, , France

Site Status

APHP CHU Henri Mondor

Créteil, , France

Site Status

CHU Dijon

Dijon, , France

Site Status

Hopital Privé de Clairval

Marseille, , France

Site Status

Hospital Prive Jacques Cartier

Massy, , France

Site Status

CH Annecy Genevois

Metz-Tessy, , France

Site Status

Clinique du Millénaire

Montpellier, , France

Site Status

NCN Nouvelles Cliniques Nantaises

Nantes, , France

Site Status

CHU Nimes Cedex

Nîmes, , France

Site Status

Chru Orleans

Orléans, , France

Site Status

CHG de Pau

Pau, , France

Site Status

CHU de Poitiers

Poitiers, , France

Site Status

CHU Amiens hopital sud

Salouël, , France

Site Status

Clinique Pasteur

Toulouse, , France

Site Status

CHU TOURS - Hospital Trousseau

Tours, , France

Site Status

Clinique Saint Gatien

Tours, , France

Site Status

CH Belfort Montbeliard

Trévenans, , France

Site Status

Hôpital Nord Franche-Comté

Trévenans, , France

Site Status

Centre Hospitalier de Valence

Valence, , France

Site Status

Charite Universitätsmedizin Berlin CBF

Berlin, , Germany

Site Status

Deutsches Herzzentrum Berlin

Berlin, , Germany

Site Status

Klinikum Links der Weser-Elektrophysiologie Bremen

Bremen, , Germany

Site Status

Augusta Krankenhaus

Düsseldorf, , Germany

Site Status

Universitaetsklinikum Duesseldorf

Düsseldorf, , Germany

Site Status

Universitares Herzentrum Hamburg/Universitaetsklinik Eppendorf

Hamburg, , Germany

Site Status

Universitaetsklinikum Heidelberg

Heidelberg, , Germany

Site Status

Oberhavel Kliniken

Hennigsdorf, , Germany

Site Status

Marien Hospital Herne

Herne, , Germany

Site Status

Universitätsklinikum Leipzig

Leipzig, , Germany

Site Status

Klinikum Leverkusen gGmbH

Leverkusen, , Germany

Site Status

Universitätsklinikum Schleswig-Holstein

Lübeck, , Germany

Site Status

Universität Mainz zentrum fur kardiologie

Mainz, , Germany

Site Status

Klinikum Mannheim GMBH

Mannheim, , Germany

Site Status

Kliniken Maria-Hilf GmbH

Mönchengladbach, , Germany

Site Status

Deutsches Herzzentrum Muenchen

Munich, , Germany

Site Status

Krankenhaus Martha Maria

Nuremberg, , Germany

Site Status

Klinikum Oldenburg AoR

Oldenburg, , Germany

Site Status

Klinikum der Universitaet Regensburg

Regensburg, , Germany

Site Status

Universitaetsklinikum Wuerzburg

Würzburg, , Germany

Site Status

Voc Cardiologia Ospedaliera Polocino di Bari

Bari, , Italy

Site Status

Magna Graecia University AUO Mater Domini di Catanzaro

Catanzaro, , Italy

Site Status

Azienda Ospedaliero - Universitaria di Ferrara

Ferrara, , Italy

Site Status

Ospedale Vito Fazzi

Lecce, , Italy

Site Status

Federico II University of Naples

Naples, , Italy

Site Status

Ospedale Monaldi

Napoli, , Italy

Site Status

Ospedale San Francesco

Nuoro, , Italy

Site Status

Azienda Ospedaliera di Padova

Padua, , Italy

Site Status

A.O.U. Policlinico Paolo Giaccone

Palmero, , Italy

Site Status

Ospedale Maria Paternò Arezzo

Ragusa, , Italy

Site Status

Fondazione Policlinico Universitario Agostino Gemelli

Rome, , Italy

Site Status

Ospedale San Pietro Fatebenefratelli

Rome, , Italy

Site Status

Policlinico Casilino

Rome, , Italy

Site Status

Ospedale Santa Maria della Misericordia di Rovigo

Rovigo, , Italy

Site Status

Azienda Socio-Sanitaria Territoriale dei Sette Laghi

Varese, , Italy

Site Status

Noordwest Ziekenhuisgroep Alkmaar

Alkmaar, , Netherlands

Site Status

Amphia Ziekenhuis

Breda, , Netherlands

Site Status

Medisch Spectrum Twente

Enschede, , Netherlands

Site Status

UMC St. Radboud

Nijmegen, , Netherlands

Site Status

Erasmus Medical Centre

Rotterdam, , Netherlands

Site Status

Maasstad Hospital

Rotterdam, , Netherlands

Site Status

Hospital da Senhora da Oliveira

Guimarães, , Portugal

Site Status

Hospital Santa Maria (Centro Hospitalar de Lisboa Norte)

Lisbon, , Portugal

Site Status

Centro Hospitalar do Porto - Hospital de Santo Antonio

Porto, , Portugal

Site Status

The National Institute of Cardiovascular Diseases

Bratislava, , Slovakia

Site Status

Hospital General Universitario

Alicante, , Spain

Site Status

Hospital Universitari Vall d'Hebron

Barcelona, , Spain

Site Status

Hospital Bellvitge

Barcelona, , Spain

Site Status

Hospital General de Ciudad Real

Ciudad Real, , Spain

Site Status

Hospital Virgen De Las Nieves

Granada, , Spain

Site Status

Hospital Infanta Leonor

Madrid, , Spain

Site Status

Hospital Clinico San Carlos

Madrid, , Spain

Site Status

Hospital La Paz

Madrid, , Spain

Site Status

Clinica Universidad de Navarra

Pamplona, , Spain

Site Status

Hospital Universitario de Canarias

Santa Cruz de Tenerife, , Spain

Site Status

Hospital Universitario Marques De Valdecilla

Santander, , Spain

Site Status

Hospital Virgen Macarena

Seville, , Spain

Site Status

Hospital nuestra senora del prado

Talavera de la Reina, , Spain

Site Status

CHUV Lausanne

Lausanne, , Switzerland

Site Status

Basildon and Thurrock University Hospitals NHS Foundation Trust

Basildon, Essex, United Kingdom

Site Status

Belfast City Hospital

Belfast, Northern Ireland, United Kingdom

Site Status

Blackpool Teaching Hospitals NHS Foundation Trust'

Blackpool, , United Kingdom

Site Status

Bristol Heart Institute

Bristol, , United Kingdom

Site Status

Papworth Hospital

Cambridge, , United Kingdom

Site Status

Addenbrookes Hospital

Cambridge, , United Kingdom

Site Status

Golden Jubilee National Hospital

Glasgow, , United Kingdom

Site Status

LHCH (Liverpool Heart and Chest Hospital)

Liverpool, , United Kingdom

Site Status

St Bartholomews Hospital

London, , United Kingdom

Site Status

Manchester Royal Infirmary

Manchester, , United Kingdom

Site Status

Northampton General Hospital

Northampton, , United Kingdom

Site Status

Derriford Hospital

Plymouth, , United Kingdom

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States Australia Austria Belgium Canada Czechia France Germany Italy Netherlands Portugal Slovakia Spain Switzerland United Kingdom

Provided Documents

Download supplemental materials such as informed consent forms, study protocols, or participant manuals.

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

C1949

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Personalized CRT - PSR
NCT03723265 COMPLETED
Optimizing CRT With ECGI
NCT03492788 TERMINATED NA
CRT RENEWAL Registry
NCT00146874 COMPLETED