Optimizing Cardiac Resynchronization

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2004-06-30

Study Completion Date

2011-12-31

Brief Summary

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Cardiac resynchronization therapy shows great promise as a method to improve ventricular function in heart failure due to dilated cardiomyopathy. It is applied to patients with class III and IV symptomatic heart failure on optimal therapy. Typical entry criteria in the trials testing resynchronization have used the electrocardiogram and a prolonged electrocardiogram (ECG) QRS interval as criteria for dyssynchrony. This is recognized to be quite limited as a tool for identifying patients. Several new echocardiographic methods for identifying dyssynchrony have been proposed. The purpose of this study is to systematically examine these multiple echocardiographic measurement techniques in three conditions:

1. in the patient's native rhythm simulated by changing the pacing system to atrial pacing only;
2. in conventional dual chamber pacing (DDD mode); and
3. during biventricular pacing. All patients entered into this study will already have had a biventricular pacemaker placed.

Detailed Description

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Conditions

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Heart Failure

Keywords

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Heart Failure Cardiac resynchronization echocardiography

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Interventions

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Cardiac resynchronization pacing

various pacemaker modes used over 1 hour

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* All patients who have previously had a resynchronization pacemaker system placed at the University of Wisconsin Hospital or at the Middleton Veterans Hospital are potentially eligible for this study.
* The study is only open to patients as enumerated above, and also patients who have good imaging windows.

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Peter S Rahko, MD

Role: PRINCIPAL_INVESTIGATOR

University of Wisconsin, Madison

Locations

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University of Wisconsin

Madison, Wisconsin, United States

Site Status

Countries

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United States

Other Identifiers

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H-2004-0335

Identifier Type: -

Identifier Source: org_study_id