Cardiac Resynchronisation Therapy In Patients With Heart Failure: Mechanistic Insights From Cardiac MRI And Electroanatomical Mapping
NCT ID: NCT04322877
Last Updated: 2020-03-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
UNKNOWN
NA
30 participants
INTERVENTIONAL
2019-09-01
2021-09-30
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
CRT In Narrow QRS Heart Failure: Mechanistic Insights From Cardiac MRI And Electroanatomical Mapping
NCT03258060
A Study Testing a New Heart Scan Method to Improve Pacemaker Treatment for Heart Failure
NCT07084467
Combining Myocardial Strain and Cardiac CT to Optimize Left Ventricular Lead Placement in CRT Treatment
NCT01426321
Cardiac Resynchronisation Study
NCT01213537
Predicting Response to Cardiac Resynchronization Therapy in Heart Failure
NCT00359372
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
NON_RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Body surface mapping and temporary pacing
Temporary pacing procedure with acute hemodynamic study and non-invasive body surface mapping.
Temporary pacing Study
Temporary delivery of CRT
Thoracic CT
As part of non-invasive mapping protocol
Acute hemodynamic study
Measurement of invasive dP/dTmax
Non-invasive body surface mapping
Cardioinsight body surface mapping
Catheter-based mapping and temporary pacing
Temporary pacing procedure with acute hemodynamic study and invasive catheter-based mapping.
Temporary pacing Study
Temporary delivery of CRT
Acute hemodynamic study
Measurement of invasive dP/dTmax
Invasive catheter-based mapping
Invasive electroanatomical mapping
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Temporary pacing Study
Temporary delivery of CRT
Thoracic CT
As part of non-invasive mapping protocol
Acute hemodynamic study
Measurement of invasive dP/dTmax
Non-invasive body surface mapping
Cardioinsight body surface mapping
Invasive catheter-based mapping
Invasive electroanatomical mapping
Other Intervention Names
Discover alternative or legacy names that may be used to describe the listed interventions across different sources.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Male or Female, aged 18 years or above.
* Either 1) has CRT system in situ or 2) has a planned CRT system implant or 3) has a planned upgrade to CRT from a standard pacemaker
* NYHA grade II-IV heart failure
* LVEF\<35%
* Intrinsic QRS duration \>120ms
* On optimum medical therapy for heart failure
* Female participants of child bearing potential must be willing to ensure that they or their partner use effective contraception during the study and for 3 months thereafter
* Able (in the Investigators opinion) and willing to comply with all study requirements.
* Willing to allow his or her General Practitioner and consultant, if appropriate, to be notified of participation in the study.
Exclusion Criteria
* Scheduled elective surgery or other procedures requiring general anaesthesia during the study.
* Participant who is terminally ill or is inappropriate for placebo medication
* Any other significant disease or disorder which, in the opinion of the Investigator, may either put the participants at risk because of participation in the study, or may influence the result of the study, or the participant's ability to participate in the study.
* Rate uncontrolled atrial fibrillation precluding a cMR
* Significant peripheral vascular disease precluding an EP study
* A contraindication to anticoagulation
* A prosthetic aortic or tricuspid valve
* Significant Aortic valve disease
* Known LV thrombus
* Insufficient capacity to consent to the study
18 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
King's College London
OTHER
Guy's and St Thomas' NHS Foundation Trust
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Guys and St Thomas' NHS Foundation Trust
London, , United Kingdom
Countries
Review the countries where the study has at least one active or historical site.
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Facility Contacts
Find local site contact details for specific facilities participating in the trial.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
125230
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.