Advance Cardiac Resynchronization Therapy (CRT) Registry

NCT ID: NCT01805154

Last Updated: 2019-08-12

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1529 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-01-31

Study Completion Date

2017-09-30

Brief Summary

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The intent of this registry is to understand comprehensive clinical care strategies for Cardiac Resynchronization Therapy (CRT) patients especially non-responders in real-world clinical practice.

Detailed Description

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Patients who are implanted CRT devices will be enrolled in the study. Once implanted, all patients will be followed at every 3 months for the first 12 months from the implant. The responder/non-responder evaluation will occur at 6 months from the implant date. The criteria used for determining the response to CRT will be captured.

During the office follow-up visits, arrhythmic episode diagnoses, device data and stored electrogram will be collected. All clinical events such as hospitalization for heart failure (HF), all-cause hospitalizations, and all-cause death will also be collected. For patients who are non-responders to CRT, any re-optimization of the device, i.e., atrioventricular and ventricle-to-ventricle interval optimization, left ventricular (LV) lead repositioning and pacing vector reconfiguration as well as modified/new clinical therapies administered in an attempt to improve HF condition will be collected.

Conditions

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Heart Failure

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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CRT patients

Patients who have received any market approved St Jude Medical CRT-D or CRT-P device

CRT Patients

Intervention Type DEVICE

This is a group of patients who are receiving bi-ventricular pacing therapy from CRT device.

Interventions

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CRT Patients

This is a group of patients who are receiving bi-ventricular pacing therapy from CRT device.

Intervention Type DEVICE

Other Intervention Names

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St Jude Medical, Any approved CRT device

Eligibility Criteria

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Inclusion Criteria

* Patient willing and able to sign informed consent
* Patients implanted with any market-approved St. Jude Medical CRT-D/P device with no prior LV lead placement

Exclusion Criteria

* Are likely to undergo heart transplantation within the next 12 months
* Are less than 18 years of age
* Are pregnant or planning to become pregnant during the duration of the study
* Are currently participating in a clinical investigation that includes an active treatment arm
* Have a life expectancy of less than 6 months
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Abbott Medical Devices

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Niraj Varma, MD

Role: STUDY_CHAIR

The Cleveland Clinic

Locations

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Alabama Cardiovascular Group, P.C.

Birmingham, Alabama, United States

Site Status

*Heart Center Research, LLC.

Huntsville, Alabama, United States

Site Status

Cardiovascular Consultants Ltd

Glendale, Arizona, United States

Site Status

Cardiovascular Associates of Mesa

Mesa, Arizona, United States

Site Status

Phoenix Cardiovascular Research Group

Phoenix, Arizona, United States

Site Status

Southern Arizona VA Health Care System

Tucson, Arizona, United States

Site Status

Comprehensive Cardiovascular

Bakersfield, California, United States

Site Status

Chula Vista Cardiac Center

Chula Vista, California, United States

Site Status

Cardiac Rhythm Specialist

Northridge, California, United States

Site Status

Claudio Bonometti MD, Inc

Santa Barbara, California, United States

Site Status

The Cardiac & Vascular Institute Research Foundation, LLC

Gainesville, Florida, United States

Site Status

Cardiology Consultants - Baptist Campus

Pensacola, Florida, United States

Site Status

Tallahassee Research Institute

Tallahassee, Florida, United States

Site Status

VA Medical Center - Tampa

Tampa, Florida, United States

Site Status

Heartland Cardiovascular Center

Joliet, Illinois, United States

Site Status

Advocate Health and Hospitals Corporation

Oakbrook Terrace, Illinois, United States

Site Status

Unitypoint

Des Moines, Iowa, United States

Site Status

Heart Care Associates PSC

Madisonville, Kentucky, United States

Site Status

Massachusetts General Hospital

Boston, Massachusetts, United States

Site Status

St. Elizabeth's Medical Center

Boston, Massachusetts, United States

Site Status

University of Michigan

Ann Arbor, Michigan, United States

Site Status

Cardiology Consultants of East Michigan

Flint, Michigan, United States

Site Status

*Thoracic Cardio Healthcare Found. (aka Sparrow Research)

Lansing, Michigan, United States

Site Status

Minneapolis Heart Institute

Minneapolis, Minnesota, United States

Site Status

Jackson Heart Clinic

Jackson, Mississippi, United States

Site Status

University of Mississippi Medical Center

Jackson, Mississippi, United States

Site Status

Cardiology Associates of North Mississippi

Tupelo, Mississippi, United States

Site Status

St. Louis University Hospital

St Louis, Missouri, United States

Site Status

Deborah Heart and Lung Center

Browns Mills, New Jersey, United States

Site Status

Lourdes Cardiology Services

Cherry Hill, New Jersey, United States

Site Status

The Cleveland Clinic Foundation

Cleveland, Ohio, United States

Site Status

Genesis HealthCare System

Zanesville, Ohio, United States

Site Status

Saint Vincent Consultants in Cardiovascular Diseases

Erie, Pennsylvania, United States

Site Status

Mountain States Medical Group Cardiology

Johnson City, Tennessee, United States

Site Status

Knoxville Cardiovascular Research Group, LLC

Knoxville, Tennessee, United States

Site Status

Texas Cardiac Arrhythmia

Austin, Texas, United States

Site Status

North Texas Heart Center

Dallas, Texas, United States

Site Status

Martha Jefferson

Charlottesville, Virginia, United States

Site Status

University of Washington Medical Center

Seattle, Washington, United States

Site Status

Cardiac Rhythm Specialists, S.C.

Milwaukee, Wisconsin, United States

Site Status

Cheyenne Cardiology Associates

Cheyenne, Wyoming, United States

Site Status

Fundacion Favaloro para la Docencia e Inv. med.

Buenos Aires, Riodepl, Argentina

Site Status

Instituto Cardiovascular Buenos Aires (ICBA)

Buenos Aires, Riodepl, Argentina

Site Status

Biocor Instituto

Nova Lima, Minas Gerais, Brazil

Site Status

Hospital Beneficiencia Portuguesa de Sao Paulo

São Paulo, Sao Pau, Brazil

Site Status

Instituto do Coracao (InCor) - HCFMUSP

São Paulo, , Brazil

Site Status

Anhui Provincial Hospital

Hefei, Anhui, China

Site Status

Guizhou Provincial People's Hospital

Guiyang, Guizhou, China

Site Status

The First Affiliated Hospital of Kunming Medical University

Kunming, Yunnan, China

Site Status

The 2nd Affiliated Hospital of Zhejiang University

Hangzhou, Zhejiang, China

Site Status

APEX Foundation

Medellín, Antioq, Colombia

Site Status

Care Institute of Medical Sciences

Ahmedabad, Gujarat, India

Site Status

Holy Family Hospital and Medical Research Center

Mumbai, Mhrshtr, India

Site Status

Ruby Hall Clinic

Pune, Mhrshtr, India

Site Status

Delhi Heart and Lung Institute

New Delhi, National Capital Territory of Delhi, India

Site Status

Escorts Heart Institute and Research Centre

New Delhi, National Capital Territory of Delhi, India

Site Status

Fortis Flt. Lt. Rajan Dhall Hospital

New Delhi, National Capital Territory of Delhi, India

Site Status

Medanta - The Medicity Hospital

Gurgaon, NCT DLH, India

Site Status

Fortis Escorts Hospital

Amritsar, Punjab, India

Site Status

Fortis Hospital

Mohali, Punjab, India

Site Status

The Madras Medical Mission

Chennai, Tmlnadu, India

Site Status

Fujita Health University School of medicine

Toyoake, Aichi-ken, Japan

Site Status

Hirosaki University Hospital

Hirosaki-shi, Aomori, Japan

Site Status

Kokura Memorial Hospital

Kitakyushu, Fukuoka, Japan

Site Status

Chiba University

Chiba, , Japan

Site Status

Heart Rhythm Management

San Juan, , Puerto Rico

Site Status

Eulji university Hospital Daejeon

Daejeon, Hoseo, South Korea

Site Status

Samsung Medical Center

Seoul, Sudogwn, South Korea

Site Status

Yonsei University Health System

Seoul, Sudogwn, South Korea

Site Status

Countries

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United States Argentina Brazil China Colombia India Japan Puerto Rico South Korea

References

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Varma N, Wang JA, Jaswal A, Sethi KK, Kondo Y, Joung B, Yoo D, Auricchio A, Singh JP, Lee K, Gold MR. CRT Efficacy in "Mid-Range" QRS Duration Among Asians Contrasted to Non-Asians, and Influence of Height. JACC Clin Electrophysiol. 2022 Feb;8(2):211-221. doi: 10.1016/j.jacep.2021.09.012. Epub 2021 Nov 24.

Reference Type DERIVED
PMID: 34838518 (View on PubMed)

Varma N, Boehmer J, Bhargava K, Yoo D, Leonelli F, Costanzo M, Saxena A, Sun L, Gold MR, Singh J, Gill J, Auricchio A. Evaluation, Management, and Outcomes of Patients Poorly Responsive to Cardiac Resynchronization Device Therapy. J Am Coll Cardiol. 2019 Nov 26;74(21):2588-2603. doi: 10.1016/j.jacc.2019.09.043.

Reference Type DERIVED
PMID: 31748196 (View on PubMed)

Provided Documents

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Document Type: Study Protocol and Informed Consent Form

View Document

Other Identifiers

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60046199

Identifier Type: -

Identifier Source: org_study_id

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