Evaluation of Left Ventricular Autothreshold, Phase Two

NCT ID: NCT01242722

Last Updated: 2012-10-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-11-30

Study Completion Date

2011-03-31

Brief Summary

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This study will collect data, from an implanted Cardiac Resynchronization Therapy-Defibrillator (CRT-D) device, to further evaluate a new feature for future heart failure devices.

Detailed Description

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ELEVATE 2.0 is an acute, prospective, multi-center, feasibility study randomized within patient test sequence and pulse width, designed to characterize the performance of the Left Ventricular Auto Threshold (LVAT) feature.

Conditions

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Heart Failure

Keywords

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Heart failure auto threshold pacing CRT-D recipients Left Ventricular (LV) evoked response signals

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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1

Two experimental and/or intervention groups under 1 arm.

CRT-D

Intervention Type DEVICE

Cardiac pacing via a pulse generator and implanted intracardiac leads

Interventions

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CRT-D

Cardiac pacing via a pulse generator and implanted intracardiac leads

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patients who have a COGNIS CRT-D device implanted for at least 24 hours, with or without a right atrial lead
* Patients who have an active LV bipolar lead
* Patients who have an active right ventricular (RV) defibrillation lead
* Patients who are willing and capable of participating in all testing associated with this Clinical Investigation
* Patients who are age 18 or above, or of legal age to give informed consent specific to state and national law

Exclusion Criteria

* Patients who have a COGNIS CRT-D that has less than or equal to one year of battery life remaining
* Patients who are pacemaker-dependent
* Patients who will not tolerate a pacing pause of up to 6 seconds
* Patients who have a unipolar LV pace/sense lead, unless the patient has any commercially available epicardial leads with at least two electrodes (from one or more leads)
* Patients with pre-existing leads other than those specified in this investigational plan
* Patients with a pre-existing unipolar pacemaker
* Patients who are unable or unwilling to maintain a supine or sitting position for 40-50 minutes
* Patients enrolled in any concurrent study, without Boston Scientific written approval
* Women who are pregnant
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Boston Scientific Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Kenneth L Ellenbogen, M.D.

Role: PRINCIPAL_INVESTIGATOR

Virginia Commonwealth University Health System

Locations

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Regional Cardiovascular Medical Center

Stuebenville, Ohio, United States

Site Status

Countries

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United States

Other Identifiers

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ELEVATE 2.0

Identifier Type: -

Identifier Source: org_study_id