Evaluation of Automatic Threshold Algorithms

NCT ID: NCT02097290

Last Updated: 2018-04-19

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

216 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-04-30

Study Completion Date

2017-05-31

Brief Summary

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This study will evaluate the PaceSafe Right Ventricular Autothreshold (RVAT) and Left Ventricular Autothreshold (LVAT) features for AUTOGEN Cardiac Resynchronization Therapy Defibrillator (CRT-D) devices.

Detailed Description

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The objective of the CAPTIVATE Clinical Study is to gather data to establish the safety and effectiveness of the PaceSafe Right Ventricular Autothreshold (RVAT) and Left Ventricular Autothreshold (LVAT) features to support the regulatory approval of the AUTOGEN CRT-D family of devices.

Conditions

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Heart Failure

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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CRT-D

For all subjects with the AUTOGEN CRT-D, the autothreshold algorithms will be evaluated

Group Type EXPERIMENTAL

CRT-D

Intervention Type DEVICE

For all subjects with the AUTOGEN CRT-D, the autothreshold algorithms will be evaluated

Interventions

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CRT-D

For all subjects with the AUTOGEN CRT-D, the autothreshold algorithms will be evaluated

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Subjects prescribed a CRT-D and indicated per guidelines, who will receive an AUTOGEN CRT-D model G160, G161, G172, G173
2. Subjects who have an implanted functional endocardial right ventricular defibrillation lead or who will receive a endocardial right ventricular defibrillation lead
3. Subjects who have an implanted functional bipolar or unipolar left ventricular lead or who will receive a bipolar or unipolar left ventricular lead
4. Subjects who are willing and capable of providing informed consent to undergo a device implant procedure, and to participate in all testing and follow-ups defined in this protocol
5. Subjects whose age is 18 or above, or of legal age to give informed consent specific to national law

Exclusion Criteria

1. Subjects who have an implanted multipolar (\>2poles) left ventricular lead or who will receive a multipolar (\>2poles) left ventricular lead
2. Subjects with an unknown model/manufacturer, or implant date for the RA, RV or LV lead
3. Subjects for whom a RV defibrillation lead manufactured by St. Jude Medical or Biotronik is implanted, is planned to be implanted, or has been abandoned
4. Implanted with an active Medtronic Sprint Fidelis® lead models: 6930, 6931, 6948 or 6949
5. Subjects with an implanted or abandoned St. Jude Medical QuickSite® or QuickFlex® lead models: 1056T, 1058T, 1156T, 1158T
6. Subjects with a RV or LV lead revision or extraction within 30 days of enrollment
7. Subjects with an implanted lead that is planned to be extracted during the study implant procedure
8. Subjects with an active implanted RA or RV lead that is greater than 10 years old, unless the lead will be abandoned
9. Subjects with an active implanted LV lead that is greater than 8 years old, unless the lead will be abandoned
10. Subjects preexisting unipolar pacemaker that will not be explanted/abandoned
11. Subjects with a life expectancy less than 6 months
12. Subjects with a prosthetic mechanical tricuspid heart valve
13. Women of childbearing age who are pregnant or plan to become pregnant. NOTE: women of childbearing potential with an uncertain pregnancy status must have a negative pregnancy test within 7 days prior to enrollment. Pregnancy tests are required as part of standard routing clinical practice at all centers whenever female patients are exposed to x-ray radiation. Since this protocol does not require any exposure of the female patients to x-ray and x-ray exposure is part of the clinical procedure, it is the responsibility of the investigators to ensure that pregnant females will not be exposed to x-ray at any time
14. Subject enrolled in a concurrent study, except national/governmental registries that do not require a signed informed consent form, without the written approval from Boston Scientific
15. Subjects who are not geographically stable, to the extent that it would prevent attending the study follow-ups at the investigational center
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Boston Scientific Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Kenneth Ellenbogen, MD

Role: PRINCIPAL_INVESTIGATOR

Virginia Commonwealth University Medical Center

Locations

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Glendale Adventist Medical Center

Glendale, California, United States

Site Status

Danbury Hospital

Danbury, Connecticut, United States

Site Status

Washington Hospital Center

Washington D.C., District of Columbia, United States

Site Status

Delray Medical Center

Atlantis, Florida, United States

Site Status

St. Vincent's Medical Center

Jacksonville, Florida, United States

Site Status

Baptist Medical Center

Jacksonville, Florida, United States

Site Status

First Coast Cardiovascular

Jacksonville, Florida, United States

Site Status

Orlando Regional Medical Center

Orlando, Florida, United States

Site Status

University Community Hospital

Trinity, Florida, United States

Site Status

Winter Haven Hospital

Winter Haven, Florida, United States

Site Status

Carle Foundation Hospital

Urbana, Illinois, United States

Site Status

IU Health LaPorte

La Porte, Indiana, United States

Site Status

St. Luke's Hospital

Cedar Rapids, Iowa, United States

Site Status

University of Iowa Hospitals and Clinics

Davenport, Iowa, United States

Site Status

Via-Christi Regional Medical Center

Wichita, Kansas, United States

Site Status

Norton Cardiovascular Associates

Louisville, Kentucky, United States

Site Status

University of Maryland Medical System

Baltimore, Maryland, United States

Site Status

Steward St. Elizabeth's Medical Center of Boston, Inc.

Boston, Massachusetts, United States

Site Status

St. John Hospital & Medical Center

Detroit, Michigan, United States

Site Status

Sparrow Health System

Lansing, Michigan, United States

Site Status

North Mississippi Medical Center

Tupelo, Mississippi, United States

Site Status

Cox Health

Springfield, Missouri, United States

Site Status

St. Patrick Hospital

Missoula, Montana, United States

Site Status

Rochester General Hospital

Rochester, New York, United States

Site Status

Wake Medical Center

Raleigh, North Carolina, United States

Site Status

Summa Health System

Akron, Ohio, United States

Site Status

Lindner Center for Research and Education

Cincinnati, Ohio, United States

Site Status

St. Elizabeth Health Center

Poland, Ohio, United States

Site Status

Good Samaritan Hospital

Lebanon, Pennsylvania, United States

Site Status

University Medical Center-Greenville Memorial Hospital

Greenville, South Carolina, United States

Site Status

Seton Medical Center

Austin, Texas, United States

Site Status

Cardiology Clinic of San Antonio

San Antonio, Texas, United States

Site Status

University of Utah Hospital and Clinics

Salt Lake City, Utah, United States

Site Status

Virginia Commonwealth University Health

Richmond, Virginia, United States

Site Status

PeaceHealth Southwest Medical

Vancouver, Washington, United States

Site Status

St. Mary's Medical Center

Huntington, West Virginia, United States

Site Status

Countries

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United States

Other Identifiers

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IDE# G130241

Identifier Type: OTHER

Identifier Source: secondary_id

CAPTIVATE

Identifier Type: -

Identifier Source: org_study_id

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