The Modulatory Effect of Oxytocin on Interoception

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

83 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-03-02

Study Completion Date

2017-09-12

Brief Summary

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This study is designed to investigate oxytocin's effects on interoception and whether these effects vary as a function of different emotional valence.

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Detailed Description

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The present study will use a double-blind, between-subject, placebo-controlled design to investigate the modulatory effect of oxytocin on interoception and whether this effect will vary as a function of emotional valence. In Experiment 1, subjects will perform a heartbeat detection task and the group differences between oxytocin and placebo groups of the interoceptive accuracy and neural activity in the core interoceptive network will be investigated. In Experiment 2, subjects will be asked to watch emotional faces while perform the heartbeat detection task. Investigators will examine whether oxytocin's effects on interoception will be varied as a function of different emotional valence.

Conditions

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Interoception

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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oxytocin

intranasal administration of oxytocin

Group Type EXPERIMENTAL

oxytocin

Intervention Type DRUG

self-administration of oxytocin (nasal spray)

placebo

intranasal administration of the same ingredient except oxytocin

Group Type PLACEBO_COMPARATOR

placebo

Intervention Type DRUG

self-administration of placebo (nasal spray)

Interventions

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oxytocin

self-administration of oxytocin (nasal spray)

Intervention Type DRUG

placebo

self-administration of placebo (nasal spray)

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Healthy subjects

Exclusion Criteria

* Subjects reported having any neurological problems, psychiatric illness or drug or alcohol abuse and none were currently taking any form of medication and had not drunk any caffeine-containing beverages on the day of the experiment.

Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes