rTMS in Facilitation of Working Memory in PD

NCT ID: NCT03059212

Last Updated: 2021-01-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-10-30

Study Completion Date

2021-12-31

Brief Summary

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Ten sessions of repetitive transcranial magnetic stimulation yield ability to upregulate the function of primary motor cortex and prefrontal cortex that play key roles in motor and frontal memory processing.

Detailed Description

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Excitatory (\>3Hz) rTMS could facilitate the brain cortex and neuroplasticity that benefits motor control and working memory when the coil is applied over primary motor cortex or dorsolateral prefrontal cortex.

Conditions

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Parkinson Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Real rTMS, sham rTMS
Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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High frequency rTMS

Real rTMS, one session per day, for 10 days

Group Type EXPERIMENTAL

rTMS

Intervention Type DEVICE

High frequency rTMS for 3 to 10 min to increase the excitability of cortex.

High frequency rTMS with cognitive training

Real rTMS and cognitive training, one session per day, for 10 days

Group Type EXPERIMENTAL

rTMS

Intervention Type DEVICE

High frequency rTMS for 3 to 10 min to increase the excitability of cortex.

Cognitive training program

Intervention Type BEHAVIORAL

A rehabilitation protocol that facilitates attention, memory, execution.

Sham rTMS

Sham rTMS, one session per day, for 10 days

Group Type SHAM_COMPARATOR

rTMS

Intervention Type DEVICE

High frequency rTMS for 3 to 10 min to increase the excitability of cortex.

Interventions

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rTMS

High frequency rTMS for 3 to 10 min to increase the excitability of cortex.

Intervention Type DEVICE

Cognitive training program

A rehabilitation protocol that facilitates attention, memory, execution.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Clinical diagnosis of Parkinson's Disease
* With symptoms of cognitive impairments, such as memory, attention, or language decline.

Exclusion Criteria

* History of seizure attack
* Alzheimer's disease
* With cardiac pacemaker implantation
Minimum Eligible Age

30 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Taipei Veterans General Hospital, Taiwan

OTHER_GOV

Sponsor Role lead

Responsible Party

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vghtpe user

principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Po-Yi Tsai, MD

Role: PRINCIPAL_INVESTIGATOR

Taipei Veterans General Hospital, Taiwan

Locations

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Taipei Veteran General Hospital

Taipei, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Po-Yi Tsai, MD

Role: CONTACT

886-22875729 ext. 3

Facility Contacts

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Po-Yi Tsai, MD

Role: primary

886-22875729 ext. 3

References

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Preston G, Anderson E, Silva C, Goldberg T, Wassermann EM. Effects of 10 Hz rTMS on the neural efficiency of working memory. J Cogn Neurosci. 2010 Mar;22(3):447-56. doi: 10.1162/jocn.2009.21209.

Reference Type RESULT
PMID: 19309294 (View on PubMed)

Related Links

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Other Identifiers

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2014-10-018A

Identifier Type: -

Identifier Source: org_study_id

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