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Dual-Task Improvement in Parkinson's Via rTMS

NCT ID: NCT07310238

Last Updated: 2025-12-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

41 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-11-15

Study Completion Date

2025-11-15

Brief Summary

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This study aimed to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) applied to the left dorsolateral prefrontal cortex on cognitive function and dual-task performance in individuals with Parkinson's disease. Participants completed ten rTMS sessions over two weeks or received sham stimulation. Cognitive status was assessed using the Montreal Cognitive Assessment, and mobility was evaluated through single-task and multiple dual-task Timed Up and Go tests. The study examined whether rTMS could enhance cognitive abilities and improve motor-cognitive performance, which are commonly impaired in Parkinson's disease and contribute to reduced functional independence. Findings indicated that rTMS led to improvements in cognition, single-task mobility, and complex dual-task performance. The intervention was well tolerated, and no adverse events related to the stimulation intensity were reported.

Detailed Description

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Parkinson's disease often leads to declines in cognition, gait performance, and the ability to manage simultaneous cognitive-motor demands. These difficulties contribute to mobility limitations, fall risk, and loss of independence in older adults. This randomized controlled study investigates whether repetitive transcranial magnetic stimulation (rTMS) targeting the left dorsolateral prefrontal cortex can enhance cognitive function and improve single- and dual-task mobility performance in individuals with Parkinson's disease. Participants complete a two-week intervention consisting of active or sham stimulation. Standardized cognitive and functional mobility assessments are administered before and after the intervention to determine the extent of change associated with rTMS. The study is designed to provide preliminary evidence on whether neuromodulation of an executive-control region can support functional motor-cognitive interactions in this population.

Conditions

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Parkinson Disease (PD) Cognition Disorders Gait Disorders, Neurologic Dual Task

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Active rTMS Group

Participants receive repetitive transcranial magnetic stimulation (rTMS) applied to the left dorsolateral prefrontal cortex at 5 Hz, 120% of the resting motor threshold, for 10 sessions over two weeks.

Group Type EXPERIMENTAL

Active Repetitive Transcranial Magnetic Stimulation (rTMS)

Intervention Type DEVICE

Repetitive transcranial magnetic stimulation applied to the left dorsolateral prefrontal cortex using a figure-8 coil. Stimulation delivered at 5 Hz, 120% of the resting motor threshold, 600 pulses per session, for 10 sessions over two weeks.

Sham Stimulation

Participants receive sham stimulation using the same coil positioning and session structure as the active rTMS group, but without active magnetic output. Sham sessions match the schedule and duration of the intervention arm.

Group Type SHAM_COMPARATOR

Sham Repetitive Transcranial Magnetic Stimulation

Intervention Type DEVICE

Sham stimulation performed using the same coil placement, session duration, and procedures as the active rTMS condition, but without magnetic output. Sessions matched in schedule and structure to the active intervention.

Interventions

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Active Repetitive Transcranial Magnetic Stimulation (rTMS)

Repetitive transcranial magnetic stimulation applied to the left dorsolateral prefrontal cortex using a figure-8 coil. Stimulation delivered at 5 Hz, 120% of the resting motor threshold, 600 pulses per session, for 10 sessions over two weeks.

Intervention Type DEVICE

Sham Repetitive Transcranial Magnetic Stimulation

Sham stimulation performed using the same coil placement, session duration, and procedures as the active rTMS condition, but without magnetic output. Sessions matched in schedule and structure to the active intervention.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Clinical diagnosis of Parkinson's disease.
* Age 65 years or older.
* Currently receiving dopaminergic therapy.
* Ability to stand independently for at least 30 seconds.

Exclusion Criteria

* Inability to walk for 2 minutes without a walking aid.
* Any contraindication to transcranial magnetic stimulation (e.g., metal implants in the head, history of seizures).
* Musculoskeletal injury or structural abnormality that could affect mobility assessment.
* Presence of another neurological disease.
Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Gaziantep

OTHER

Sponsor Role lead

Responsible Party

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Halil Ibrahim ERGEN

Assistant professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Gaziantep University

Gaziantep, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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2022/345

Identifier Type: -

Identifier Source: org_study_id