Effects of rTMS on Corticomotor Excitability and Balance Performance in Parkinson's Disease
NCT ID: NCT07195773
Last Updated: 2026-02-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
21 participants
INTERVENTIONAL
2024-12-16
2025-11-19
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
DOUBLE
Study Groups
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Group A
Patients in this group first undergo high-frequency rTMS treatment, followed by a two-week rest period, then proceed to low-frequency rTMS after another two-week rest, and finally receive sham stimulation rTMS.
rTMS high-frequency 1Hz 80%RMT rTMS low-frequency 1Hz 80%RMT rTMS sham 10HZ 20%RMT
rTMS
investigate the effects of repetitive transcranial magnetic stimulation on corticomotor excitability, balance performance, and mobility in patients with Parkinson's disease, and to further explore the effects on corticomotor excitability by single low-frequency and high-frequency repetitive transcranial magnetic stimulation. Participants will receive different stimulation approaches in sequences: high-frequency rTMS, low-frequency rTMS, and sham rTMS. They will be randomly assigned to three groups with different stimulation sequences. After each single stimulation, corticomotor excitability, balance, and motor symptoms will be measured. In this study, eighteen PD patients with Hoehn and Yahr stage 1 to 3 will be recruited.
Group B
Patients in this group first undergo low-frequency rTMS treatment, followed by a two-week rest period, then proceed to high-frequency rTMS after another two-week rest, and finally receive sham stimulation rTMS.
rTMS high-frequency 1Hz 80%RMT rTMS low-frequency 1Hz 80%RMT rTMS sham 10HZ 20%RMT
rTMS
investigate the effects of repetitive transcranial magnetic stimulation on corticomotor excitability, balance performance, and mobility in patients with Parkinson's disease, and to further explore the effects on corticomotor excitability by single low-frequency and high-frequency repetitive transcranial magnetic stimulation. Participants will receive different stimulation approaches in sequences: high-frequency rTMS, low-frequency rTMS, and sham rTMS. They will be randomly assigned to three groups with different stimulation sequences. After each single stimulation, corticomotor excitability, balance, and motor symptoms will be measured. In this study, eighteen PD patients with Hoehn and Yahr stage 1 to 3 will be recruited.
Group C
Patients in this group first undergo sham stimulation rTMS treatment, followed by a two-week rest period, then proceed to high-frequency rTMS after another two-week rest, and finally receive low-frequency rTMS.
rTMS high-frequency 1Hz 80%RMT rTMS low-frequency 1Hz 80%RMT rTMS sham 10HZ 20%RMT
rTMS
investigate the effects of repetitive transcranial magnetic stimulation on corticomotor excitability, balance performance, and mobility in patients with Parkinson's disease, and to further explore the effects on corticomotor excitability by single low-frequency and high-frequency repetitive transcranial magnetic stimulation. Participants will receive different stimulation approaches in sequences: high-frequency rTMS, low-frequency rTMS, and sham rTMS. They will be randomly assigned to three groups with different stimulation sequences. After each single stimulation, corticomotor excitability, balance, and motor symptoms will be measured. In this study, eighteen PD patients with Hoehn and Yahr stage 1 to 3 will be recruited.
Interventions
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rTMS
investigate the effects of repetitive transcranial magnetic stimulation on corticomotor excitability, balance performance, and mobility in patients with Parkinson's disease, and to further explore the effects on corticomotor excitability by single low-frequency and high-frequency repetitive transcranial magnetic stimulation. Participants will receive different stimulation approaches in sequences: high-frequency rTMS, low-frequency rTMS, and sham rTMS. They will be randomly assigned to three groups with different stimulation sequences. After each single stimulation, corticomotor excitability, balance, and motor symptoms will be measured. In this study, eighteen PD patients with Hoehn and Yahr stage 1 to 3 will be recruited.
Eligibility Criteria
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Inclusion Criteria
2. Age: 40-85 years
3. Hoehn and Yahr scale (H\&Y scale) : I-III
4. Appropriate prescribed medication, and regular intake for more than 2 weeks
5. Can walk more than 10m with or without the use of assistive devices
Exclusion Criteria
2. Any neurological surgery that would affect participation in this experiment
3. Orthopedic pathology and Cardiovascular issues
4. MMSE≦24
5. Exercise used for treatment in the last three months
6. Contraindications for transcranial magnetic stimulation (Presence of metal implants in the head and neck, a pacemaker in the chest, personal or family history of epilepsy, recent brain injury, currently taking antidepressant medication.)
40 Years
85 Years
ALL
No
Sponsors
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Chung Shan Medical University
OTHER
Responsible Party
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Principal Investigators
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LIU HSIN-HSUAN, PhD
Role: STUDY_CHAIR
Assistant Professor
HONG SONG-PING, BSc
Role: PRINCIPAL_INVESTIGATOR
student
Locations
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Chung Shan Medical Unirversity
Taichung, Southern District, Taiwan
Countries
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Other Identifiers
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CS2-23200
Identifier Type: -
Identifier Source: org_study_id
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