Pharmacokinetics of Epinephrine During Cardiac Arrest

NCT ID: NCT03036202

Last Updated: 2019-08-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

8 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-06-26

Study Completion Date

2018-10-12

Brief Summary

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To determine the pharmacokinetics of epinephrine during cardiac arrest.

Detailed Description

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The aim of out study is to determine the pharmacokinetics in humans during cardiac arrest, following a single dose of epinephrine. Venous samples will be withdrawn every minute the first five minutes following a single dose.

The aim of the study is to determine T1/2 in a clinical setting and to determine time to peak concentration.

Conditions

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Cardiac Arrest

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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one group

All patients treated for cardiac arrest, meeting our inclusions criteria will be enrolled in the study. No interventions regarding the national guidelines will be jeopardized, as the plasma concentration following a single dose of epinephrine will be measured in all patient.

Epinephrine

Intervention Type DRUG

This is truly an observational study to determine T1/2 for epinephrine and time to peak concentration following a single dose of epinephrine in a cardiac arrest setting

Interventions

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Epinephrine

This is truly an observational study to determine T1/2 for epinephrine and time to peak concentration following a single dose of epinephrine in a cardiac arrest setting

Intervention Type DRUG

Other Intervention Names

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Adrenaline

Eligibility Criteria

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Inclusion Criteria

* Age 18-85 yrs
* Witnessed non-traumatic cardiac arrest.
* Probable cardiac origin
* Treated by Bergen Emergency Medical Services

Exclusion Criteria

* Terminal illness
* Residents of nursery homes
* Obvious dead
* Hypothermic patients
* Epinephrine administered before arrival of study physician
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Haukeland University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Baard E Heradstveit, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Haukeland University Hospital

Locations

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Haukeland University Hospital

Bergen, N, Norway

Site Status

Countries

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Norway

Other Identifiers

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1471-74

Identifier Type: -

Identifier Source: org_study_id

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