Care Optimization Through Patient and Hospital Engagement Clinical Trial for Heart Failure

NCT ID: NCT03035474

Last Updated: 2021-01-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

5749 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-04-21

Study Completion Date

2020-12-31

Brief Summary

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CONNECT-HF is a large-scale, pragmatic, cluster-randomized clinical trial to evaluate the effect of a customized, multifaceted, health system-level quality-improvement (QI) program compared with usual care on heart failure (HF) outcomes and HF quality-of-care metrics.

Detailed Description

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This trial will be a large-scale, pragmatic, cluster-randomized clinical trial to evaluate the effect of a customized, multifaceted, health system-level quality-improvement (QI) program compared with usual care on heart failure (HF) outcomes and HF quality-of-care metrics. Outcomes will be assessed following discharge for participants hospitalized with acute HF and reduced left ventricular ejection fraction. All participants in the trial will be consented for follow-up as part of the CONNECT-HF registry on clinical outcomes, medication use, and participant-centered outcomes, including quality-of-life (QOL) assessments will be collected up to 12 months post-discharge at pre-specified intervals (6 weeks and 3, 6, and 12 months).

The health-system QI program will involve site visits and ongoing mentoring from teams of healthcare professionals with specialized training and field experience to help health systems and individual hospitals to design local QI plans.

A key substudy will assess a participant-engagement strategy (digital) of a mobile application utilizing behavioral tools to reinforce health behaviors, including self-monitoring/self-management and medication adherence.

Follow-up will occur via a centralized telephone interview by trained personnel via the DCRI Call Center. At each interview, participants will be asked to report current medications, rehospitalizations, and QOL assessments. Based on participant-reported events, medical billing data for rehospitalizations, emergency department visits, and procedures will be obtained.

Quality of life assessments will include the Kansas City Cardiomyopathy Questionnaire (KCCQ) and EuroQOL five dimensions questionnaire (EQ-5D).

Conditions

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Heart Failure

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Direct & Digital

Health system engagement to improve local QI programs and patient engagement to improve self-management/medication adherence

Group Type OTHER

Digital Engagement

Intervention Type OTHER

Patient engagement to improve self-management/medication adherence

Direct Engagement

Intervention Type OTHER

Health system engagement to improve local QI programs

Direct & Registry

Health system engagement to improve local QI programs and patient and control

Group Type OTHER

Direct Engagement

Intervention Type OTHER

Health system engagement to improve local QI programs

Digital & Registry

Patient engagement to improve self-management/medication adherence and control

Group Type OTHER

Digital Engagement

Intervention Type OTHER

Patient engagement to improve self-management/medication adherence

Registry

Control

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Digital Engagement

Patient engagement to improve self-management/medication adherence

Intervention Type OTHER

Direct Engagement

Health system engagement to improve local QI programs

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age ≥ 18 years
* Acute HF as a primary cause of hospitalization

* Hospitalizations for acute HF will be determined by local clinician-investigators but should include the following:
* Symptoms (eg, dyspnea, fatigue), signs (eg, elevated jugular venous pressure, peripheral edema), or laboratory/imaging evidence of HF (eg, pulmonary congestion on chest x-ray, elevated natriuretic peptide levels) during the hospitalization and
* Treatments aimed at acute HF (eg, intravenous diuretics, vasodilators, or inotropes)
* LVEF ≤ 40% based on last local measurement using echocardiography, multigated acquisition scan, computed tomography (CT) scanning, magnetic resonance imaging, or ventricular angiography
* Planned discharge to home or other supported care facility where patients are individually responsible for medication management

Exclusion Criteria

* Prior heart transplant or current/planned left ventricular assistance device
* Chronic kidney disease requiring dialysis
* Terminal illness other than HF, such as malignancy, or with a life expectancy of less than 1 year as determined by the enrolling clinician-investigator
* Unable to participate in longitudinal follow-up, such as plans to move outside the US in the following year
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Duke Clinical Research Institute

OTHER

Sponsor Role collaborator

Duke University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Adam DeVore, MD, MHS

Role: PRINCIPAL_INVESTIGATOR

Duke University

Locations

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University of Alabama Hospital

Birmingham, Alabama, United States

Site Status

Providence Alaska Medical Center

Anchorage, Alaska, United States

Site Status

Sparks Regional Medical Center

Fort Smith, Arkansas, United States

Site Status

Arkansas Heart Hospital and Clinics

Little Rock, Arkansas, United States

Site Status

San Gorgonio Memorial Hospital

Banning, California, United States

Site Status

Memorial Medical Center

Modesto, California, United States

Site Status

Dignity Health Sequoia Hospital

Redwood City, California, United States

Site Status

Riverside Community Hospital

Riverside, California, United States

Site Status

Sutter Medical Center

Sacramento, California, United States

Site Status

Stanford University

Stanford, California, United States

Site Status

Torrance Memorial Medical Center

Torrance, California, United States

Site Status

University of Colorado Hospital

Aurora, Colorado, United States

Site Status

UC Health Memorial

Colorado Springs, Colorado, United States

Site Status

Northern Colorado Medical Center

Greeley, Colorado, United States

Site Status

Stamford Hospital

Stamford, Connecticut, United States

Site Status

JFK Medical Center

Atlantis, Florida, United States

Site Status

Manatee Memorial Hospital

Bradenton, Florida, United States

Site Status

Blake Medical Center

Bradenton, Florida, United States

Site Status

Broward Health Imperial Point

Fort Lauderdale, Florida, United States

Site Status

Holy Cross Hospital

Fort Lauderdale, Florida, United States

Site Status

Broward Health Medical Center

Fort Lauderdale, Florida, United States

Site Status

Mayo Clinic Florida

Jacksonville, Florida, United States

Site Status

Orlando Health

Orlando, Florida, United States

Site Status

Cardiovascular Institute of Northwest Florida

Panama City, Florida, United States

Site Status

Baptist Hospital

Pensacola, Florida, United States

Site Status

Sacred Heart Hospital

Pensacola, Florida, United States

Site Status

Sarasota Memorial Hospital

Sarasota, Florida, United States

Site Status

South Miami Hospital

South Miami, Florida, United States

Site Status

Bayfront Health - St. Petersburg

St. Petersburg, Florida, United States

Site Status

Northside Hospital

St. Petersburg, Florida, United States

Site Status

Florida Hospital Tampa

Tampa, Florida, United States

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St. Joseph's Hospital

Tampa, Florida, United States

Site Status

Winter Haven Hospital

Winter Haven, Florida, United States

Site Status

Piedmont Athens Regional Medical Center

Athens, Georgia, United States

Site Status

Grady Memorial Hospital

Atlanta, Georgia, United States

Site Status

AU Medical Center

Augusta, Georgia, United States

Site Status

Northeast Georgia Medical Center

Gainesville, Georgia, United States

Site Status

Medical Center, Navicent Health (THE)

Macon, Georgia, United States

Site Status

The Queens Medical Center

Honolulu, Hawaii, United States

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Copley Memorial Hospital

Aurora, Illinois, United States

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Presence Mercy Medical Center

Aurora, Illinois, United States

Site Status

John H. Stroger Jr. Hospital of Cook County

Chicago, Illinois, United States

Site Status

University of Illinois Hospital and Health Sciences System

Chicago, Illinois, United States

Site Status

Specialty Physicians of Illinois

Olympia Fields, Illinois, United States

Site Status

Saint Anthony Medical Center

Rockford, Illinois, United States

Site Status

St Johns Hospital

Springfield, Illinois, United States

Site Status

The Carle Foundation Hospital

Urbana, Illinois, United States

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Indiana University Health Bloomington

Bloomington, Indiana, United States

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Indiana University Health Ball Memorial Hospital

Muncie, Indiana, United States

Site Status

Reid Health

Richmond, Indiana, United States

Site Status

Genesis Medical Center-Davenport

Davenport, Iowa, United States

Site Status

King's Daughters Medical Center

Ashland, Kentucky, United States

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KentuckyOne Health - Saint Joseph Hospital

Lexington, Kentucky, United States

Site Status

Norton Women and Children's Hospital

Louisville, Kentucky, United States

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Norton Brownsboro Hospital

Louisville, Kentucky, United States

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Baptist Health Madisonville

Madisonville, Kentucky, United States

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Rapides Regional Medical Center

Alexandria, Louisiana, United States

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Natchitoches Regional Medical Center

Natchitoches, Louisiana, United States

Site Status

Ochsner Medical Center

New Orleans, Louisiana, United States

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Louisiana State University-Health Science Center- Shreveport

Shreveport, Louisiana, United States

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Anne Arundel Medical Center

Annapolis, Maryland, United States

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Sinai Hospital of Baltimore

Baltimore, Maryland, United States

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Suburban Hospital

Bethesda, Maryland, United States

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MedStar Southern Maryland Hospital Center

Clinton, Maryland, United States

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Johns Hopkins University

Columbia, Maryland, United States

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Adventist HealthCare Shady Grove

Rockville, Maryland, United States

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Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States

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Cape Code Hospital

Hyannis, Massachusetts, United States

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St. Joseph Mercy Hospital

Ann Arbor, Michigan, United States

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Wayne State University

Detroit, Michigan, United States

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Henry Ford Health System

Detroit, Michigan, United States

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St. John Hospital and Medical Center

Detroit, Michigan, United States

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Hurley Medical Center

Flint, Michigan, United States

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Spectrum Health

Grand Rapids, Michigan, United States

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McLaren Greater Lansing

Lansing, Michigan, United States

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St. John Macomb-Oakland

Madison Heights, Michigan, United States

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MidMichigan Medical Center Midland

Midland, Michigan, United States

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McLaren Macomb

Mount Clemens, Michigan, United States

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McLaren - Northern Michigan

Petoskey, Michigan, United States

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Lakeland Hospital

Saint Joseph, Michigan, United States

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St. John Macomb Hospital

Warren, Michigan, United States

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St Lukes Hospital

Duluth, Minnesota, United States

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Memorial Hospital at Gulfport

Gulfport, Mississippi, United States

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St. Mary's Medical Center

Blue Springs, Missouri, United States

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St. Joseph Medical Center

Kansas City, Missouri, United States

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North Kansas City Hospital

North Kansas City, Missouri, United States

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Cox Medical Centers

Springfield, Missouri, United States

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Billings Clinic Hospital

Billings, Montana, United States

Site Status

Glacier View Research Institute-Cardiology

Kalispell, Montana, United States

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Bryan Medical Center

Lincoln, Nebraska, United States

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University Medical Center

Las Vegas, Nevada, United States

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Southern NH Medical Center

Nashua, New Hampshire, United States

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Our Lady of Lourdes Medical Center

Camden, New Jersey, United States

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Englewood Hospital and Medical Center

Englewood, New Jersey, United States

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Monmouth Medical Center

Long Branch, New Jersey, United States

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Jersey Shore University Medical Center

Neptune City, New Jersey, United States

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Saint Michael's Medical Center

Newark, New Jersey, United States

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AtlantiCare Regional Medical Center

Pomona, New Jersey, United States

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Valley Hospital

Ridgewood, New Jersey, United States

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Robert Wood Johnson University Hospital Somerset

Somerville, New Jersey, United States

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Holy Name Medical Center

Teaneck, New Jersey, United States

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University of New Mexico Health Sciences Center

Albuquerque, New Mexico, United States

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Albany Medical Center Hospital

Albany, New York, United States

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St. Peter's Hospital

Albany, New York, United States

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Huntington Hospital

Huntington, New York, United States

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United Health Services Hospitals

Johnson City, New York, United States

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Mount Sinai Beth Israel

New York, New York, United States

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Ellis Hospital

Schenectady, New York, United States

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Staten Island University Hospital

Staten Island, New York, United States

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Richmond University Medical Center

Staten Island, New York, United States

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University Hospital (Stony Brook)

Stony Brook, New York, United States

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St. Joseph's Hospital

Syracuse, New York, United States

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Montefiore Medical Center

The Bronx, New York, United States

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Charlotte-Mecklenburg Hospital Authority

Charlotte, North Carolina, United States

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Duke University Hospital

Durham, North Carolina, United States

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Duke Cardiology of Lumberton

Lumberton, North Carolina, United States

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Duke Raleigh Hospital

Raleigh, North Carolina, United States

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WakeMed

Raleigh, North Carolina, United States

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New Hanover Regional Medical Center

Wilmington, North Carolina, United States

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Novant Health Forsyth Medical Center

Winston-Salem, North Carolina, United States

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Altru Health System

Grand Forks, North Dakota, United States

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Summa Health

Akron, Ohio, United States

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Miami Valley Hospital

Dayton, Ohio, United States

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University Hospitals - Elyria Medical Center

Elyria, Ohio, United States

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Springfield Regional Medical Center

Springfield, Ohio, United States

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Oklahoma University Health Science Center

Oklahoma City, Oklahoma, United States

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Integris Baptist Medical Center

Oklahoma City, Oklahoma, United States

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OHSU Hospital and Clinics

Portland, Oregon, United States

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Memorial Medical Center

Johnstown, Pennsylvania, United States

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WellSpan Good Samaritan Hospital

Lebanon, Pennsylvania, United States

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Self Regional Healthcare

Greenwood, South Carolina, United States

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Jackson-Madison County General Hospital

Jackson, Tennessee, United States

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University of Tennessee Medical Center

Knoxville, Tennessee, United States

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Baptist Memorial Hospital

Memphis, Tennessee, United States

Site Status

Centennial Medical Center

Nashville, Tennessee, United States

Site Status

Texas Cardiac Arrhythmia Research Foundation

Austin, Texas, United States

Site Status

Medical City Dallas Hospital

Dallas, Texas, United States

Site Status

Plaza Medical Center of Fort Worth

Fort Worth, Texas, United States

Site Status

Ben Taub General Hospital

Houston, Texas, United States

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Christus Good Shepherd Medical Center

Longview, Texas, United States

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The Heart Hospital Baylor Plano

Plano, Texas, United States

Site Status

Methodist Hospital

San Antonio, Texas, United States

Site Status

Guadalupe Regional Medical Center

Seguin, Texas, United States

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University of Texas Health Science Center at Tyler

Tyler, Texas, United States

Site Status

Inova Alexandria Hospital

Alexandria, Virginia, United States

Site Status

Riverside Regional Medical Center

Newport News, Virginia, United States

Site Status

Sentara Norfolk General Hospital

Norfolk, Virginia, United States

Site Status

CJW Medical Center

Richmond, Virginia, United States

Site Status

Harborview Medical Center

Seattle, Washington, United States

Site Status

Wheeling Hospital

Wheeling, West Virginia, United States

Site Status

Mayo Clinic Health System Franciscan Medical Center

La Crosse, Wisconsin, United States

Site Status

Ascension Columbia St. Mary's Hospital

Milwaukee, Wisconsin, United States

Site Status

Ascension-All Saints

Racine, Wisconsin, United States

Site Status

Waukesha Memorial Hospital

Waukesha, Wisconsin, United States

Site Status

Countries

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United States

References

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Rao VN, Kaltenbach LA, Granger BB, Fonarow GC, Al-Khalidi HR, Albert NM, Butler J, Allen LA, Lanfear DE, Ariely D, Miller JM, Brodsky MA, Lalonde TA, Lafferty JC, Granger CB, Hernandez AF, Devore AD; Durham, North Carolina; Los Angeles, California; Cleveland, Ohio; Jackson, Misssissippi, Aurora, Colorado; Detroit, Michigan; Ewa Beach, Hawaii; Staten Island, New York. The Association of Digital Health Application Use With Heart Failure Care and Outcomes: Insights From CONNECT-HF. J Card Fail. 2022 Oct;28(10):1487-1496. doi: 10.1016/j.cardfail.2022.07.050. Epub 2022 Jul 26.

Reference Type DERIVED
PMID: 35905867 (View on PubMed)

DeVore AD, Granger BB, Fonarow GC, Al-Khalidi HR, Albert NM, Lewis EF, Butler J, Pina IL, Allen LA, Yancy CW, Cooper LB, Felker GM, Kaltenbach LA, McRae AT, Lanfear DE, Harrison RW, Disch M, Ariely D, Miller JM, Granger CB, Hernandez AF. Effect of a Hospital and Postdischarge Quality Improvement Intervention on Clinical Outcomes and Quality of Care for Patients With Heart Failure With Reduced Ejection Fraction: The CONNECT-HF Randomized Clinical Trial. JAMA. 2021 Jul 27;326(4):314-323. doi: 10.1001/jama.2021.8844.

Reference Type DERIVED
PMID: 34313687 (View on PubMed)

DeVore AD, Granger BB, Fonarow GC, Al-Khalidi HR, Albert NM, Lewis EF, Butler J, Pina IL, Heidenreich PA, Allen LA, Yancy CW, Cooper LB, Felker GM, Kaltenbach LA, McRae AT, Lanfear DE, Harrison RW, Kociol RD, Disch M, Ariely D, Miller JM, Granger CB, Hernandez AF. Care Optimization Through Patient and Hospital Engagement Clinical Trial for Heart Failure: Rationale and design of CONNECT-HF. Am Heart J. 2020 Feb;220:41-50. doi: 10.1016/j.ahj.2019.09.012. Epub 2019 Oct 23.

Reference Type DERIVED
PMID: 31770656 (View on PubMed)

Other Identifiers

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Pro00074513

Identifier Type: -

Identifier Source: org_study_id

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