Multi-Center Project: Building Electronic Tools To Enhance and Reinforce CArdiovascular REcommendations - Heart Failure

NCT ID: NCT06457152

Last Updated: 2026-01-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

3000 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-04-04

Study Completion Date

2026-03-29

Brief Summary

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This study will test an automated, electronic health record (EHR-)embedded alert to improve prescribing of guideline-directed medical therapy for patients with heart failure and reduced ejection fraction (HFrEF). The investigators have previously tested and implemented this alert at NYU Langone Health (NYULH), and will now test and implement this alert across three other health systems.

Detailed Description

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Conditions

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Heart Failure

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

NONE

Study Groups

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Intervention

Participants who are randomized to receive the intervention (i.e., displaying the automated EHR-embedded alert).

Group Type EXPERIMENTAL

EHR-Emedded Alert

Intervention Type OTHER

For patients randomized to the intervention group, an automated, EHR-embedded alert will be visible in the patient's chart that promotes appropriate medical therapy for patients with HFrEF.

Standard of Care

Participants who are randomized to the control group (i.e., not displaying the automated EHR-embedded alert).

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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EHR-Emedded Alert

For patients randomized to the intervention group, an automated, EHR-embedded alert will be visible in the patient's chart that promotes appropriate medical therapy for patients with HFrEF.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patient with an encounter visit at participating cardiology practice during the study period
* Patient with EF of less than or equal to 40% on most recent echocardiogram at the time of visit
* Patient ages 18-90

Exclusion Criteria

* Pregnancy
* Ventricular assist device
* Hospice
* Cardiac amyloid
* Medication-specific exclusion for MRA: most recent systolic blood pressure less than 105 mm Hg, most recent potassium \< 5.1, any potassium \> 5.5, most recent glomerular filtration rate \< 30 (using MDRD equation), or a documented MRA allergy.
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Massachusetts General Hospital

OTHER

Sponsor Role collaborator

University of Pennsylvania

OTHER

Sponsor Role collaborator

OhioHealth

OTHER

Sponsor Role collaborator

NYU Langone Health

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Amrita Mukhopadhyay

Role: PRINCIPAL_INVESTIGATOR

NYU Langone Health

Locations

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University of Massachusetts

Boston, Massachusetts, United States

Site Status

NYU Langone Health

New York, New York, United States

Site Status

OhioHealth

Columbus, Ohio, United States

Site Status

University of Pennsylvania

Philadelphia, Pennsylvania, United States

Site Status

Countries

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United States

Other Identifiers

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24-00179

Identifier Type: -

Identifier Source: org_study_id

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