User Performance Evaluation of Contour® Next One, Accu-Chek® Aviva Connect, FreeStyle Freedom Lite, OneTouch® Verio and GlucoMen® Areo Blood Glucose Monitoring Systems Following ISO 15197:2013

NCT ID: NCT03033849

Last Updated: 2017-09-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

189 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-01-31

Study Completion Date

2017-03-31

Brief Summary

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The user performance evaluation shows whether people with diabetes are able to obtain accurate measurement results with a blood glucose monitoring system. In this study, user performance evaluation will be performed for Contour® Next One (Ascensia Diabetes Care GmbH), Accu-Chek® Aviva Connect (Roche Diabetes Care GmbH), FreeStyle Freedom Lite (Abbott Diabetes Care Inc.), OneTouch® Verio (LifeScan Europe) and GlucoMen® areo A. Menarini Diagnostics S.r.l. (based on ISO 15197:2013; EN ISO 15197:2015, clause 8.

For each BGMS, measurement procedures for user performance evaluation will be performed with 1 test meter and 1 reagent system lot by the study subjects.

The same meter and an additional test meter will be used for double measurements performed by study personnel (with the same reagent system lot used by subjects).

Detailed Description

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Conditions

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Diabetes Mellitus

Study Groups

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Blood glucose measurement

Every study subject shall test three out of the five devices. The testing order of the BGMS will be changed on each subject to minimize any order effects on measurement results.

Group Type EXPERIMENTAL

Blood glucose monitoring system for self-testing Contour® Next One

Intervention Type DEVICE

This is a user performance study, that is intended to show whether people with diabetes are able to obtain accurate measurement results with a blood glucose monitoring system (BGMS).

The subjects' measurement technique (e.g. applying blood onto the system reagent, reading the result) will be observed and documented by study personnel.

Immediately after the measurement by the subject, the study personnel will perform a measurement with the same test meter.

Measurement results obtained by the subjects with the BGMS will be compared to measurement results obtained with the comparison method.

Sample collection for the comparison measurement will be performed by study personnel within 5 min after the subject's measurement with the test meter.

The samples will be collected from the subjects' skin puncture (if possible), an additional skin puncture (if required) will be documented.

An additional skin puncture will be performed by study personnel with single-use lancing devices.

Blood glucose monitoring system for self-testing Accu-Chek® Aviva Connect

Intervention Type DEVICE

Blood glucose monitoring system for self-testing FreeStyle Freedom Lite

Intervention Type DEVICE

Blood glucose monitoring system for self-testing OneTouch® Verio

Intervention Type DEVICE

Blood glucose monitoring system for self-testing GlucoMen® areo

Intervention Type DEVICE

Interventions

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Blood glucose monitoring system for self-testing Contour® Next One

This is a user performance study, that is intended to show whether people with diabetes are able to obtain accurate measurement results with a blood glucose monitoring system (BGMS).

The subjects' measurement technique (e.g. applying blood onto the system reagent, reading the result) will be observed and documented by study personnel.

Immediately after the measurement by the subject, the study personnel will perform a measurement with the same test meter.

Measurement results obtained by the subjects with the BGMS will be compared to measurement results obtained with the comparison method.

Sample collection for the comparison measurement will be performed by study personnel within 5 min after the subject's measurement with the test meter.

The samples will be collected from the subjects' skin puncture (if possible), an additional skin puncture (if required) will be documented.

An additional skin puncture will be performed by study personnel with single-use lancing devices.

Intervention Type DEVICE

Blood glucose monitoring system for self-testing Accu-Chek® Aviva Connect

Intervention Type DEVICE

Blood glucose monitoring system for self-testing FreeStyle Freedom Lite

Intervention Type DEVICE

Blood glucose monitoring system for self-testing OneTouch® Verio

Intervention Type DEVICE

Blood glucose monitoring system for self-testing GlucoMen® areo

Intervention Type DEVICE

Other Intervention Names

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Contour® Next One, Accu-Chek® Aviva Connect, FreeStyle Freedom Lite, OneTouch® Verio, GlucoMen® areo

Eligibility Criteria

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Inclusion Criteria

* Male or female, with type 1 diabetes, type 2 diabetes or subjects without diabetes
* Signed informed consent form
* Minimum age of 18 years
* Subjects are legally competent and capable to understand character, meaning and consequences of the study.
* If blood glucose values \< 80 mg/dl or \> 300 mg/dl shall be measured after short term alteration in insulin therapy:
* Male or female with type 1 diabetes and intensified insulin therapy or insulin pump therapy.
* Signature of subjects to document consent with these procedures on informed consent form.

Exclusion Criteria

* Pregnancy or lactation period
* Severe acute disease (at the study physician's discretion)
* Severe chronic disease with potential risk during the test procedures (at the study physician's discretion)
* Current constitution that compromises the subject's capability to participate in the study (at the study physician's discretion)
* Being unable to give informed consent
* \< 18 years
* Legally incompetent
* Being committed to an institution (e.g. psychiatric clinic)
* Language barriers potentially compromising an adequate compliance with study procedures
* Dependent on investigator or sponsor
* If blood glucose values \< 80 mg/dl shall be measured after short term alteration in insulin therapy, subjects with type 1 diabetes, suffering from:
* Coronary heart disease
* Condition after myocardial infarction
* Condition after cerebral events
* Peripheral arterial occlusive disease
* Hypoglycemia unawareness
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Ascensia Diabetes Care

INDUSTRY

Sponsor Role collaborator

Institut für Diabetes-Technologie Forschungs- und Entwicklungsgesellschaft mbH an der Universität Ulm

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Institut für Diabetes-Technologie Forschungs- und Entwicklungsgesellschaft mbH an der Universität Ulm

Ulm, Baden-Wurttemberg, Germany

Site Status

Countries

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Germany

References

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Jendrike N, Baumstark A, Pleus S, Liebing C, Kamecke U, Haug C, Freckmann G. Accuracy of five systems for self-monitoring of blood glucose in the hands of adult lay-users and professionals applying ISO 15197:2013 accuracy criteria and potential insulin dosing errors. Curr Med Res Opin. 2019 Feb;35(2):301-311. doi: 10.1080/03007995.2018.1491832. Epub 2018 Jul 19.

Reference Type DERIVED
PMID: 29927663 (View on PubMed)

Other Identifiers

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IDT-1608-AL

Identifier Type: -

Identifier Source: org_study_id

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