A Clinical Study to Evaluate the Use of Episodic, Intensive Blood Glucose Monitoring in Persons With Non-insulin Treated Type 2 Diabetes

NCT ID: NCT00674986

Last Updated: 2013-10-21

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

522 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-03-31

Study Completion Date

2010-02-28

Brief Summary

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This randomized, parallel group study will determine whether the use of episodic, intensive glucose monitoring via the Accu-Chek 360 view blood glucose analysis system has a positive effect on overall glycemic control. Patients will be randomized into either the 'usual care' group, or the 'interventional group' supplemented with the Accu-Chek 360 view blood glucose analysis system. The effect of each treatment regimen on glycemic control will be assessed by measurement of change in baseline HbA1c values at 12 months. The anticipated time on study treatment is 1 year, and the target sample size is 504 individuals.

Detailed Description

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Conditions

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Diabetes Mellitus, Type 2

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Active Control Group (ACG)

Participants in the Active Control Group received enhanced standard of care (more frequent clinic visits, free blood glucose meters and strips and point-of-care Hemoglobin A1c (HbA1c) test) for management of their Type 2 diabetes.

Group Type OTHER

Accu-Chek Aviva Glucose Meter

Intervention Type DEVICE

Structured Testing Group (STG)

Participants in the Structured Testing Group in addition to enhanced standard of care for the treatment of their Type 2 diabetes used the ACCU-CHEK® 360° View blood glucose analysis system (Tool) to monitor glucose levels at least quarterly.

Group Type EXPERIMENTAL

Accu-Chek 360° View Blood Glucose Analysis Tool

Intervention Type DEVICE

Accu-Chek Aviva Glucose Meter

Intervention Type DEVICE

Interventions

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Accu-Chek 360° View Blood Glucose Analysis Tool

Intervention Type DEVICE

Accu-Chek Aviva Glucose Meter

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Adult patients \>= 25 years of age
* Type 2 diabetes for \>= 1 year
* Hemoglobin A1c \>= 7.5% and \<=11%
* Diabetes managed by exercise and diet, prescription oral medication or an injectable incretin mimetic

Exclusion Criteria

* Type 1 diabetes
* On any type of insulin therapy at start of study
Minimum Eligible Age

25 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hoffmann-La Roche

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bettina Petersen

Role: STUDY_DIRECTOR

Roche Diagnostics GmbH

Locations

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Mobile, Alabama, United States

Site Status

Pell City, Alabama, United States

Site Status

Chipley, Florida, United States

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Marianna, Florida, United States

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Pembroke Pines, Florida, United States

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Tampa, Florida, United States

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Tampa, Florida, United States

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Atlanta, Georgia, United States

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Atlanta, Georgia, United States

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Chicago, Illinois, United States

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O'Fallon, Illinois, United States

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Fishers, Indiana, United States

Site Status

Indianapolis, Indiana, United States

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Indianapolis, Indiana, United States

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Flint, Michigan, United States

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Hickory, North Carolina, United States

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Raleigh, North Carolina, United States

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Wilmington, North Carolina, United States

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Winston-Salem, North Carolina, United States

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Cuyahoga Falls, Ohio, United States

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Zanesville, Ohio, United States

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Pottstown, Pennsylvania, United States

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Pottstown, Pennsylvania, United States

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High Point, South Carolina, United States

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Lancaster, South Carolina, United States

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Mt. Pleasant, South Carolina, United States

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Bristol, Tennessee, United States

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Crossville, Tennessee, United States

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Abingdon, Virginia, United States

Site Status

Countries

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United States

References

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Fisher L, Polonsky W, Parkin CG, Jelsovsky Z, Amstutz L, Wagner RS. The impact of blood glucose monitoring on depression and distress in insulin-naive patients with type 2 diabetes. Curr Med Res Opin. 2011 Nov;27 Suppl 3:39-46. doi: 10.1185/03007995.2011.619176. Epub 2011 Sep 14.

Reference Type DERIVED
PMID: 21916532 (View on PubMed)

Polonsky WH, Fisher L, Schikman CH, Hinnen DA, Parkin CG, Jelsovsky Z, Petersen B, Schweitzer M, Wagner RS. Structured self-monitoring of blood glucose significantly reduces A1C levels in poorly controlled, noninsulin-treated type 2 diabetes: results from the Structured Testing Program study. Diabetes Care. 2011 Feb;34(2):262-7. doi: 10.2337/dc10-1732.

Reference Type DERIVED
PMID: 21270183 (View on PubMed)

Polonsky W, Fisher L, Schikman C, Hinnen D, Parkin C, Jelsovsky Z, Amstutz L, Schweitzer M, Wagner R. The value of episodic, intensive blood glucose monitoring in non-insulin treated persons with Type 2 Diabetes: design of the Structured Testing Program (STeP) study, a cluster-randomised, clinical trial [NCT00674986]. BMC Fam Pract. 2010 May 18;11:37. doi: 10.1186/1471-2296-11-37.

Reference Type DERIVED
PMID: 20482765 (View on PubMed)

Other Identifiers

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RDC-MI&A-01-2007

Identifier Type: -

Identifier Source: secondary_id

RD000590

Identifier Type: -

Identifier Source: org_study_id