A Comparison of Cognitive Training Approaches in Psychotic Disorders

NCT ID: NCT03024203

Last Updated: 2018-11-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

70 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-08-31

Study Completion Date

2018-03-31

Brief Summary

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Cognitive remediation (CR) is the best treatment to improve neurocognitive abilities for individuals with psychosis, however, there is no gold standard method of cognitive remediation available. Cognitive training refers to the training component of CR in which people practice computerized exercises that train specific cognitive abilities. There is no agreed upon approach within the field as to the type of training that is most effective with some studies, training higher level cognitive abilities, some training perceptual abilities, and others training general cognitive skills. This study will directly compare two competing methods of cognitive training on measures of neurophysiology, neurocognition, functional competence, and real-world functional performance.

Detailed Description

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Conditions

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Psychotic Disorders

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Executive Training

Executive Training (ET) involves training on computerized cognitive exercises that have graded increases in difficulty so that the participant is always challenged. A therapist will be in the room with participants to address any difficulties with the program and facilitate generation of strategies. ET will be delivered in both individual and group settings.

Group Type EXPERIMENTAL

Cognitive Remediation - Executive Training

Intervention Type BEHAVIORAL

Cognitive remediation is a cognitive and behavioural therapy designed to improve cognitive skills such as memory, and problem solving ability.

Perceptual Training

Perceptual Training (PT) involves training on computerized cognitive exercises that have graded increases in difficulty so that the participant is always challenged. A therapist will be in the room with participants to address any difficulties with the program and facilitate generation of strategies. PT will be delivered in both individual and group settings.

Group Type EXPERIMENTAL

Cognitive Remediation - Perceptual Training

Intervention Type BEHAVIORAL

Cognitive remediation is a cognitive and behavioural therapy designed to improve cognitive skills such as attention, and processing speed.

Interventions

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Cognitive Remediation - Executive Training

Cognitive remediation is a cognitive and behavioural therapy designed to improve cognitive skills such as memory, and problem solving ability.

Intervention Type BEHAVIORAL

Cognitive Remediation - Perceptual Training

Cognitive remediation is a cognitive and behavioural therapy designed to improve cognitive skills such as attention, and processing speed.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* psychotic disorder
* No previous cognitive remediation in past 6 months

Exclusion Criteria

* Brain injury
* Substance abuse
* Neurocognitive disorder
* Developmental Disability
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Queen's University

OTHER

Sponsor Role lead

Responsible Party

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Dr. Christopher Bowie

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Queen's University

Kingston, Ontario, Canada

Site Status

Countries

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Canada

References

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Best MW, Milanovic M, Iftene F, Bowie CR. A Randomized Controlled Trial of Executive Functioning Training Compared With Perceptual Training for Schizophrenia Spectrum Disorders: Effects on Neurophysiology, Neurocognition, and Functioning. Am J Psychiatry. 2019 Apr 1;176(4):297-306. doi: 10.1176/appi.ajp.2018.18070849. Epub 2019 Mar 8.

Reference Type DERIVED
PMID: 30845819 (View on PubMed)

Other Identifiers

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PSYC-173-16

Identifier Type: -

Identifier Source: org_study_id

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