Preimplant Site Augmentation Using MPM Versus Autogenous Bone Graft

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-01-31

Study Completion Date

2017-12-31

Brief Summary

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Using growth factors obtained from patient's venous blood mixed with particulate autogenous bone the study compares bone gain by implant with gold standards.

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Detailed Description

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To study the effectiveness of MPM in ridge augmentation with implant insertion compared with autogenous bone graft.

-PICO-

Population (P): Patients with defective maxillary alveolar ridge requiring implant insertion.

Intervention (I): Ridge augmentation with MPM.

Comparator (C): Autogenous bone graft.

Outcome (O): Patient satisfaction - Implant stability.

Conditions

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Bone Resorption

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Autogenous bone graft (Gold Standard).

Patients with defective maxillary alveolar ridges requiring implant insertion will have Autogenous bone graft (Gold standard) and collagen membrane to be used for bone augmentation around exposed threads of inserted dental implants.

Group Type EXPERIMENTAL

Autogenous bone graft (gold standard).

Intervention Type OTHER

Exposed implant threads are to be covered with autogenous bone and collagen membrane.

MPM Augmentation.

Mineralized plasmatic matrix (MPM) to be used without collagen membrane to augment the defect in the maxillary bone and cover the exposed threads of the dental implants.

Group Type ACTIVE_COMPARATOR

Mineralized plasmatic matrix (MPM).

Intervention Type OTHER

By using venoud blood from the patient, together with bone graft, a centrifuge will be used to obtain the top layer after centrifuging blood at 3000 RPM, for 10 minutes , Which will result if sticky bone graft consistency after mixing.

Interventions

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Mineralized plasmatic matrix (MPM).

By using venoud blood from the patient, together with bone graft, a centrifuge will be used to obtain the top layer after centrifuging blood at 3000 RPM, for 10 minutes , Which will result if sticky bone graft consistency after mixing.

Intervention Type OTHER

Autogenous bone graft (gold standard).

Exposed implant threads are to be covered with autogenous bone and collagen membrane.

Intervention Type OTHER

Other Intervention Names

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Sticky bone graft. Autobone.

Eligibility Criteria

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Inclusion Criteria

1. Medically free patients.
2. Evaluated bone height on CBCT to be (0-4 mm buccal bone dehiscence) and width (not less than 4.5 mm)
3. Patients with Anterior maxillary defective partially edentulous ridge.
4. Age between 18 and 40 years.
5. Both sexes.
6. Patients physically able to tolerate surgical and restorative procedures.
7. Patients with an opposing tooth to the pre-implant site.
8. Good oral hygiene.
9. Highly motivated patients.

Exclusion Criteria

1. Patients allergic to local anesthetic agent.
2. Pregnant or lactating females.
3. Presence of any pathosis in the pre-implant site.
4. Presence of any mucosal disease.
5. Presence of parafunctional habits.
6. History of oral radiotherapy.
7. History of prolonged steroids use.
8. Psychological disorders.

Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes