FLuid Responsiveness Prediction Using EXtra Systoles

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-01-31

Study Completion Date

2017-09-30

Brief Summary

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In this study, the investigators propose to investigate a novel technique for fluid responsiveness prediction. It is based on the occurrence of an extra systole, which induces a preload variation: Extra systoles are comprised by, first, the premature/ectopic beat with decreased cardiac preload, then, the post-ectopic beat with moderately increased preload.

Consequently, the post ectopic beat is associated with a Frank-Starling curve right shift but is otherwise a normal sinus beat. As such, the post-ectopic beat elucidates and predicts the hemodynamic effect of increasing preload, i.e. giving fluids

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Detailed Description

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Conditions

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Coronary Artery Bypass Graft

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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fluid challenge

Group Type OTHER

fluid challenge

Intervention Type OTHER

At two pre-defined time points during the procedure, enrolled patients will receive a fluid bolus of 5 ml/kg during 5 minutes

Interventions

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fluid challenge

At two pre-defined time points during the procedure, enrolled patients will receive a fluid bolus of 5 ml/kg during 5 minutes

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients requiring elective CABG or OPCAB surgery
* Patient's age ≥ 18 years

Exclusion Criteria

* Patient refusal
* Pregnancy
* EF \< 35%
* End stage kidney failure (defined by the need for haemodialysis)
* Patients with atrial fibrillation or frequent and coupled extra systoles (e.g. trigemini)

Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No