Effects of Prolonged Roll-tilt in Healthy Human Subjects

NCT ID: NCT02980419

Last Updated: 2020-01-07

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-06-30
• Study Completion Date: 2020-05-31

Brief Summary

The long-term goal of this research is to advance the investigators knowledge of how the brain combines the information of multiple sensory systems coding for spatial oriention and how adaptation to vestibular imbalance influences spatial orientation. In healthy human subjects verticality perception is accurate while upright. After prolonged roll-tilt, humans show a systematic bias in perceived direction towards the previous roll-tilted position (so-called "post-tilt bias"). This effect could either be related to adaptation to the roll-tilted position (shifting the "null" position) or it could be related to changes in torsional eye position due to prolonged static roll-tilt (ocular counter-roll). While in the first case a post-tilt bias is predicted independently of the experimental paradigm used, the second hypothesis predicts a post-tilt bias only if retinal cues are integrated. In order to evaluate these hypotheses, the investigators will assess perceived vertical using both vision-dependent and vision-independent paradigms.

Conditions

Adaptation Reaction

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

intervention arm

In each participant the investigators will assess verticality perception in whole-body upright position by use of the SVV, the SPV and the SHV after static roll-tilt at ±90deg over 5min. Measurements will be obtained on a motor-driven turntable and two different roll-tilt positions will be applied (±90°). A visual line (SVV), a rod (SHV) or the turntable itself will be adjusted to indicate perceived direction of vertical. A total of three measuring sessions, each lasting about 60 minutes are scheduled.

Group Type: EXPERIMENTAL

presentation of visual and vestibular stimuli

Intervention Type: BEHAVIORAL

In each participant the investigators will assess verticality perception in whole-body upright position by use of the SVV, the SPV and the SHV after static roll-tilt at ±90deg over 5min. Measurements will be obtained on a motor-driven turntable and two different roll-tilt positions will be applied (±90°). A visual line (SVV), a rod (SHV) or the turntable itself will be adjusted to indicate perceived direction of vertical. A total of three measuring sessions, each lasting about 60 minutes are scheduled.

Interventions

presentation of visual and vestibular stimuli

In each participant the investigators will assess verticality perception in whole-body upright position by use of the SVV, the SPV and the SHV after static roll-tilt at ±90deg over 5min. Measurements will be obtained on a motor-driven turntable and two different roll-tilt positions will be applied (±90°). A visual line (SVV), a rod (SHV) or the turntable itself will be adjusted to indicate perceived direction of vertical. A total of three measuring sessions, each lasting about 60 minutes are scheduled.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• ages 18-65 years
• informed consent

Exclusion Criteria

• peripheral-vestibular deficit
• disturbed consciousness
• history of sensory deficits
• visual field deficits
• other neurological or systemic disorder which can cause dementia or cognitive dysfunction
• intake of antidepressants, sedatives, or neuroleptics
• pregnancy, unless excluded by a negative pregnancy test
• known neck pain or status post neck trauma

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Zurich

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

University Hospital Zurich, Dept. of Neurology

Zurich, Canton of Zurich, Switzerland

Site Status: RECRUITING

Countries

Switzerland

Central Contacts

Dominik Straumann, MD

Role: CONTACT

dominik.straumann@usz.ch

+41442551111

Alexander A Tarnutzer, MD

Role: CONTACT

alexander.tarnutzer@usz.ch

+41442551111

Facility Contacts

Alexander Tarnutzer, MD

Role: primary

alexander.tarnutzer@usz.ch

+41442551111

Other Identifiers

post_tilt_study

Identifier Type: -

Identifier Source: org_study_id