Verticality Perception - Effects of Prolonged Roll-tilt in Healthy Human Subjects

NCT ID: NCT02760173

Last Updated: 2018-07-02

Basic Information

• Recruitment Status: WITHDRAWN
• Clinical Phase: NA
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-06-01
• Study Completion Date: 2018-06-28

Brief Summary

The long-term goal of this research is to advance our knowledge of how the brain combines the information of multiple sensory systems coding for spatial orientation and how adaptation to vestibular imbalance influences spatial orientation. In healthy human subjects verticality perception is accurate while upright. After prolonged roll-tilt, humans show a systematic bias in perceived direction towards the previous roll-tilted position (so-called "post-tilt bias"). Here we evaluate different potential explanations for this bias using both vision-dependent and vision-independent paradigms of verticality perception.

Conditions

Vestibular; Perception

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Single intervention arm

This is the only arm in this study, measuring verticality perception after prolonged roll-tilt over 5min.

Group Type: EXPERIMENTAL

perception of vertical after static roll-tilt over 5min

Intervention Type: OTHER

subjects will indicate perceived direction of vertical after 5min of static whole-body roll-tilt.

Interventions

perception of vertical after static roll-tilt over 5min

subjects will indicate perceived direction of vertical after 5min of static whole-body roll-tilt.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

1. ages 18-65 years

2. informed consent

Exclusion Criteria

1. peripheral-vestibular deficit

2. disturbed consciousness

3. history of sensory deficits

4. visual field deficits

5. other neurological or systemic disorder which can cause dementia or cognitive dysfunction

6. intake of antidepressants, sedatives, or neuroleptics

7. pregnancy, unless excluded by a negative pregnancy test

8. known neck pain or status post neck trauma

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Zurich

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Dominik Straumann, MD

Role: PRINCIPAL_INVESTIGATOR

University of Zurich, Switzerland

Other Identifiers

vert_perc_posttilt

Identifier Type: -

Identifier Source: org_study_id