Crave Crush Neuroimaging Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-12-31

Study Completion Date

2016-06-30

Brief Summary

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The purpose of the research is to test whether a gymnemic acids (GA) lozenge will reduce reward region response to intake of high-sugar food and ad lib candy intake and whether the GA lozenge reduced reward region response to anticipated intake of high-sugar food and high-sugar food pictures relative to a placebo lozenge.

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Detailed Description

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Test the hypothesis that an acute dose of Crave Crush will produce greater reductions in reward region response to a taste of a high-sugar/high-fat beverage and anticipated receipt of this beverage than a placebo dose.

Test the hypothesis that a dose of Crave Crush will result in reduced ad lib candy intake while the participants complete a survey after the fMRI scan. Participants will receive a second dose of Crave Crush or placebo. They will then be placed in a room to complete a few surveys. A bowl of candy will be placed on the table. Participants will be told that the candy is left over from their assessment and that they are free to have as much as they like, because the candy must be discarded after each participant.

Conditions

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Obesity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Crave Crush

Crave Crush is a plant-based tablet that alters taste perception by affecting sweet taste receptors on the tongue.

Group Type EXPERIMENTAL

Crave Crush

Intervention Type DIETARY_SUPPLEMENT

Crave Crush is a dietary supplement that affects sweet taste receptors on the tongue.

Placebo

The placebo tablet is comparable in taste and is comprised primarily of sorbitol.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DIETARY_SUPPLEMENT

The placebo tablet is comparable in taste and is comprised primarily of sorbitol.

Interventions

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Crave Crush

Crave Crush is a dietary supplement that affects sweet taste receptors on the tongue.

Intervention Type DIETARY_SUPPLEMENT

Placebo

The placebo tablet is comparable in taste and is comprised primarily of sorbitol.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Between 18 and 50 years old
* report having a sweet tooth
* report desire to lose weight
* Body Mass Index between 18 and 40

Exclusion Criteria

* major psychiatric disorders
* serious health problems (e.g., diabetes)
* habitual use of psychoactive drugs or medications
* contraindications for MRI scanning (e.g., ferromagnetic braces)
* gluten or lactose intolerance
* a vegan diet.

Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes