The Effect of Brain Stimulation (tDCS) in Food Cravings Control in Overweight/Obese Women
NCT ID: NCT04420767
Last Updated: 2020-06-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
30 participants
INTERVENTIONAL
2017-01-04
2021-12-31
Brief Summary
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Detailed Description
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All eligible participants will engage in a behavioral intervention (Go-No Go task), known to enhance control over food cravings, and will be randomly assigned to receive either tDCS or sham stimulation to the right prefrontal cortex of the brain during 8 20-min daily sessions.
Primary outcome: score changes in eating behaviors scales (YFAS and TFEQ), scales will be applied at baseline and at the end of the 8 brain stimulation sessions.
Secondary outcomes: changes in diet, brain function (brain MRI/MRS) Other outcomes: food cravings scales and impulse control scales and cognitive function.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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tDCS and Go-No Go task
Certain randomly assigned participants will receive tDCS to the DLPFC for 8 daily 20-minute sessions, with a TDCS amplitude of 2 mAmps.
During the tDCS session, individuals will perform a 10-min computerized Go-No Go task
tDCS
Individuals undergo 20min daily sessions receiving actual tDCS to the brain (to the right DLPFC: dorsolateral prefrontal cortex)
Go-No GO task
During the brain stimulation sessions, all individuals will be asked to perform a 10 min-computerized task related to inhibitory control (Go-No Go)
Sham brain stimulation and Go-No Go task
Certain randomly assigned participants will receive Sham Stimulation to the DLPFC for 8 daily 20-min sessions. The Sham stimulation is an inactive form of stimulation.
During the sham brain stimulation session, individuals will perform a 10-min computerized Go-No Go task
Sham brain stimulation
Individuals undergo 20min daily sessions receiving sham stimulation to the brain (to the right DLPFC: dorsolateral prefrontal cortex)
Go-No GO task
During the brain stimulation sessions, all individuals will be asked to perform a 10 min-computerized task related to inhibitory control (Go-No Go)
Interventions
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tDCS
Individuals undergo 20min daily sessions receiving actual tDCS to the brain (to the right DLPFC: dorsolateral prefrontal cortex)
Sham brain stimulation
Individuals undergo 20min daily sessions receiving sham stimulation to the brain (to the right DLPFC: dorsolateral prefrontal cortex)
Go-No GO task
During the brain stimulation sessions, all individuals will be asked to perform a 10 min-computerized task related to inhibitory control (Go-No Go)
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Any contraindication to undergo MRI
* Use of psychotropic medications and/or opiate pain medications.
* Current or past alcohol or drug abuse problem or smoking
* Pregnancy
* Current use of weight loss medication or currently participating in a weight loss program.
* History of seizures, epilepsy or factors/medications associated with lowered seizure threshold.
* History of brain disease or major neurological disorder or mental disorder
* History of brain surgery or history of loss of consciousness \>15 min
* History of major gastrointestinal surgery including weight loss surgery
* History of endocrine imbalances including diabetes, thyroid disease, Cushing's disease, metabolic syndrome and polycystic ovary.
18 Years
40 Years
FEMALE
Yes
Sponsors
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University of California, Los Angeles
OTHER
Responsible Party
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Claudia P. Sanmiguel, MD
Health Sciences Assistant Professor
Principal Investigators
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Claudia P Sanmiguel, MD
Role: PRINCIPAL_INVESTIGATOR
University of California, Los Angeles
Locations
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University of California
Los Angeles, California, United States
Countries
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Other Identifiers
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IRB#15-001929
Identifier Type: -
Identifier Source: org_study_id
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