Effects of tDCS on Cognitive Flexibility and EEG Oscillations in Orthorexia Nervosa
NCT ID: NCT07141979
Last Updated: 2025-08-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
48 participants
INTERVENTIONAL
2025-09-01
2026-07-31
Brief Summary
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Detailed Description
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Informed Voluntary Consent Form Demographic Information Form Edinburgh Hand Preference Survey Beck Depression Scale Test of Orthorexia Nervosa (TON-17) Cognitive Flexibility Task EEG and tDCS devices Statistics: Statistical analyses will be conducted using SPSS 25.0 (Statistical Package for Social Sciences) for Windows, and EEG data will be analyzed using the Brain-Vision Analyzer software.
Descriptive statistics for group variables such as age and education will be presented as means and standard deviations, while gender will be reported as frequency and percentage.
The normality of the distribution of variables will be assessed using the Kolmogorov-Smirnov test, and appropriate parametric or non-parametric tests will be applied based on the results.
To evaluate pre-test and post-test data for cognitive flexibility and EEG measures in the experimental and control groups, Repeated Measures Analysis of Variance (within- and between-subjects) or its non-parametric equivalent, the Friedman Test, will be used.
For all statistical tests, a significance level of p \< 0.05 will be considered as the threshold for statistical significance.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
SINGLE
Study Groups
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Experimental group
Participants will take active tDCS stimulation
Active tDCS
20 min, 2 milliampere (mA), Anodal tDCS in left DLPFC
Control group
Participants will take sham tDCS stimulation
Sham tDCS
20 min, left DLPFC Sham tDCS
Interventions
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Active tDCS
20 min, 2 milliampere (mA), Anodal tDCS in left DLPFC
Sham tDCS
20 min, left DLPFC Sham tDCS
Eligibility Criteria
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Inclusion Criteria
* Having a score of 17 or less on the Beck Depression Inventory
* Having a score of 61 or more on the Test for Orthorexia Nervosa (TON-17) for the orthorexia group
Exclusion Criteria
* Currently taking medication that alters the cortical excitability level,
* Having visual defects that cannot be corrected with glasses
* Use of intracranial metal objects, implanted stimulating devices or pacemakers
18 Years
40 Years
ALL
Yes
Sponsors
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Istanbul Medipol University Hospital
OTHER
Responsible Party
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Bahar Güntekin
Prof. Dr., Principal Investigator
Locations
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Istanbul Medipol University
Istanbul, , Turkey (Türkiye)
Countries
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Central Contacts
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Facility Contacts
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References
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Emek Savas DD, Yerlikaya D, G Yener G, Oktem Tanor O. Validity, Reliability and Normative Data of the Stroop Test Capa Version. Turk Psikiyatri Derg. 2020 Spring;31(1):9-21. doi: 10.5080/u23549. English, Turkish.
Du M, Peng Y, Li Y, Zhu Y, Yang S, Li J, Zou F, Wang Y, Wu X, Zhang Y, Zhang M. Effect of trait anxiety on cognitive flexibility: Evidence from event-related potentials and resting-state EEG. Biol Psychol. 2022 Apr;170:108319. doi: 10.1016/j.biopsycho.2022.108319. Epub 2022 Mar 22.
Dong G, Wang Y, Chen X. Anodal occipital tDCS enhances spontaneous alpha activity. Neurosci Lett. 2020 Mar 16;721:134796. doi: 10.1016/j.neulet.2020.134796. Epub 2020 Jan 30.
Donaldson PH, Kirkovski M, Yang JS, Bekkali S, Enticott PG. High-definition tDCS to the right temporoparietal junction modulates slow-wave resting state power and coherence in healthy adults. J Neurophysiol. 2019 Oct 1;122(4):1735-1744. doi: 10.1152/jn.00338.2019. Epub 2019 Aug 28.
Darna M, Stolz C, Jauch HS, Strumpf H, Hopf JM, Seidenbecher CI, Schott BH, Richter A. Frontal theta oscillations and cognitive flexibility: Age-related modulations in EEG activity. Aging Brain. 2025 Jun 24;8:100142. doi: 10.1016/j.nbas.2025.100142. eCollection 2025.
Chrysikou EG, Hamilton RH, Coslett HB, Datta A, Bikson M, Thompson-Schill SL. Noninvasive transcranial direct current stimulation over the left prefrontal cortex facilitates cognitive flexibility in tool use. Cogn Neurosci. 2013;4(2):81-9. doi: 10.1080/17588928.2013.768221.
Cavinato M, Genna C, Formaggio E, Gregorio C, Storti SF, Manganotti P, Casanova E, Piperno R, Piccione F. Behavioural and electrophysiological effects of tDCS to prefrontal cortex in patients with disorders of consciousness. Clin Neurophysiol. 2019 Feb;130(2):231-238. doi: 10.1016/j.clinph.2018.10.018. Epub 2018 Nov 29.
Borwick C, Lal R, Lim LW, Stagg CJ, Aquili L. Dopamine depletion effects on cognitive flexibility as modulated by tDCS of the dlPFC. Brain Stimul. 2020 Jan-Feb;13(1):105-108. doi: 10.1016/j.brs.2019.08.016. Epub 2019 Aug 31.
Berchio C, Annen LC, Bouamoud Y, Micali N. Temporal dynamics of cognitive flexibility in adolescents with anorexia nervosa: A high-density EEG study. Eur J Neurosci. 2023 Mar;57(6):962-980. doi: 10.1111/ejn.15921. Epub 2023 Feb 7.
Alizadehgoradel J, Nejati V, Sadeghi Movahed F, Imani S, Taherifard M, Mosayebi-Samani M, Vicario CM, Nitsche MA, Salehinejad MA. Repeated stimulation of the dorsolateral-prefrontal cortex improves executive dysfunctions and craving in drug addiction: A randomized, double-blind, parallel-group study. Brain Stimul. 2020 May-Jun;13(3):582-593. doi: 10.1016/j.brs.2019.12.028. Epub 2020 Jan 3.
Aboulafia-Brakha T, Manuel AL, Ptak R. Prefrontal transcranial direct current stimulation facilitates affective flexibility. Neuropsychologia. 2016 Jun;86:13-8. doi: 10.1016/j.neuropsychologia.2016.03.030. Epub 2016 Mar 30.
Other Identifiers
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E-10840098-202.3.02-35.59
Identifier Type: -
Identifier Source: org_study_id
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