Optimal TCI Regimen for Sedation of Elderly Undergoing Fiberoptic Bronchoscopy
NCT ID: NCT02927587
Last Updated: 2016-10-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
70 participants
INTERVENTIONAL
2015-11-30
2016-04-30
Brief Summary
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Detailed Description
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Target-Controlled Infusion (TCI) of Propofol has been proved to be a safe agent for conscious sedation in flexible bronchoscopy (FB) due to its fast onset of action and rapid recovery time. By virtue of an aging population, the number of bronchoscopy performed will likely increase in the elderly patients , however, the target setting of "effect-site"concentration (Cet) of propofol is still unclear among this population.
The aim of this study was to compare two induction Cet of propofol in elderly patients undergoing flexible bronchoscopy.
METHODS: Seventy patients were randomly divided into 2 groups . All patients were of American Society of Anesthesiologists (ASA) physical status of I-III, aged more than 65 years old and between 45 and 100 kg in weight. The induction Cet was targeted respectively at 1 and 2 ug/ml. Upon reaching the modified observer's assessment of alertness/sedation(MOAA/S) score 0-3, the Cet was increased or reduced during the procedures and the Ce level was set for the maintenance of sedation. Induction time, diagnostic procedures as well as the occurrence of adverse events such as apnea , hypotension or hypertension, heart rate, oxygen saturation (SpO2) ,any cardiac event, cough score, frequency of adjustments of drug doses were recorded.
The patient will be monitored during the procedure with periodic blood pressure checks, respiratory rate, continuous electrocardiogram monitoring of heart and oxygen measurement.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
SINGLE
Study Groups
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The induction Cet of propofol 1
The induction Cet of propofol was targeted at 1 ug/ml.
The induction Cet of propofol
The induction Cet of propofol was targeted respectively at 1 and 2 ug/ml.
The induction Cet of propofol 2
The induction Cet of propofol was targeted at 2 ug/ml.
The induction Cet of propofol
The induction Cet of propofol was targeted respectively at 1 and 2 ug/ml.
Interventions
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The induction Cet of propofol
The induction Cet of propofol was targeted respectively at 1 and 2 ug/ml.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* an ASA physical status I and III
Exclusion Criteria
* bradycardia
* hypotension
65 Years
ALL
Yes
Sponsors
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The Second Affiliated Hospital of Dalian Medical University
OTHER
Responsible Party
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Locations
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The Second Hospital of Dalian Medical University
Dalian, Liaoning, China
Countries
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Other Identifiers
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brofiber
Identifier Type: -
Identifier Source: org_study_id
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