Teenagers: Impact of Eccentric eXercise Training on Overweight and Obesity

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-01-01

Study Completion Date

2020-01-31

Brief Summary

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Nowadays, eccentric exercise can be realized in a dynamic way with an ergocycle which permits eccentric (ECC) lower limbs contractions at a defined power output. With this type of ergometer, O2 consumption (VO2) in ECC is three fold lower than in concentric (CON) for the same power output. Consequently, ECC program could be used in chronic disorders with limited capacities, such as obesity.

The investigators hypothesis that an eccentric training program, as it will induce higher mechanical constraints, would improve body composition, especially by reducing fat mass. This effect could be explained by an increased rest energy expenditure and a better improvement in biological parameters (particularly lipid profile and insulin-resistance) after ECC training (versus CON training).

This study aims to compare the modification of fat mass after an ECC program versus a CON program at the same VO2.. The secondary goal is to assess the physiological mechanisms involved in the modification of body composition.

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Detailed Description

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40 obese adolescents will be randomized into 2 groups: CON or EXC. The patients of ECC group will follow habituation sessions (2 weeks) to avoid the secondary muscular effects of high intensity eccentric exercise. The training program will last 12 weeks for the two groups. Before and after, each subjects will participate to the following measurements: total and segmental body composition (DXA), aerobic capacities (maximal incremental exercise test, VO2max), muscular lower limbs strength (isometric and isokinetic dynamometer), rest energy expenditure (indirect calorimetry), biological parameters (lipid profile, insulin-resistance), physical activity (actimetry), food intakes and quality of life (questionnaires).

Conditions

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Adolescents (12 to 17 Years Old) Obese (BMI>90th Percentile)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Participants

Study Groups

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Concentric cycling exercise (CON)

40 obese adolescents will be randomized into 2 groups: CON or EXC

Group Type EXPERIMENTAL

Cycling exercises

Intervention Type OTHER

All measurements are performed before and after the training program (12 weeks)

eccentric cycling exercise (EXC)

40 obese adolescents will be randomized into 2 groups: CON or EXC

Group Type EXPERIMENTAL

Cycling exercises

Intervention Type OTHER

All measurements are performed before and after the training program (12 weeks)

Interventions

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Cycling exercises

All measurements are performed before and after the training program (12 weeks)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Adolescent (12 to 17 years old)
* BMI\>90th percentile
* Post puberty (Tanner 3 to 5)
* Inactive (\<10 METS/h/week)
* No other chronic disease (cardio pulmonary, osteo articulary or muscular diseases), no surgery during the last 3 months, no genetic obesity and no contraindication to physical activity