Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
60 participants
OBSERVATIONAL
2016-08-31
2017-03-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Interventions
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endocan
to look series Endocan level for 5 days in intubated patients
Eligibility Criteria
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Inclusion Criteria
* Patients whether intubated and connected to a mechanical ventilator
Exclusion Criteria
* Patients with brain tumors
* patients with acute and chronic renal failure
* Patients with hypertension
* Patients with previously diagnosed infection
* Patients with extubated
* patients using antibiotics or corticosteroids before bronchoalveolar lavage fluid samples taken
18 Years
ALL
No
Sponsors
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Erzincan University
OTHER
Responsible Party
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ILKE KUPELI
assist. prof.
Locations
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Erzincan University
Erzincan, , Turkey (Türkiye)
Countries
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Central Contacts
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Facility Contacts
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References
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Fagon JY, Chastre J, Wolff M, Gervais C, Parer-Aubas S, Stephan F, Similowski T, Mercat A, Diehl JL, Sollet JP, Tenaillon A. Invasive and noninvasive strategies for management of suspected ventilator-associated pneumonia. A randomized trial. Ann Intern Med. 2000 Apr 18;132(8):621-30. doi: 10.7326/0003-4819-132-8-200004180-00004.
Mayhall CG. Ventilator-associated pneumonia or not? Contemporary diagnosis. Emerg Infect Dis. 2001 Mar-Apr;7(2):200-4. doi: 10.3201/eid0702.010209.
Gibot S, Cravoisy A, Levy B, Bene MC, Faure G, Bollaert PE. Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia. N Engl J Med. 2004 Jan 29;350(5):451-8. doi: 10.1056/NEJMoa031544.
Bechard D, Gentina T, Delehedde M, Scherpereel A, Lyon M, Aumercier M, Vazeux R, Richet C, Degand P, Jude B, Janin A, Fernig DG, Tonnel AB, Lassalle P. Endocan is a novel chondroitin sulfate/dermatan sulfate proteoglycan that promotes hepatocyte growth factor/scatter factor mitogenic activity. J Biol Chem. 2001 Dec 21;276(51):48341-9. doi: 10.1074/jbc.M108395200. Epub 2001 Oct 5.
Bechard D, Meignin V, Scherpereel A, Oudin S, Kervoaze G, Bertheau P, Janin A, Tonnel A, Lassalle P. Characterization of the secreted form of endothelial-cell-specific molecule 1 by specific monoclonal antibodies. J Vasc Res. 2000 Sep-Oct;37(5):417-25. doi: 10.1159/000025758.
Luyt CE, Combes A, Reynaud C, Hekimian G, Nieszkowska A, Tonnellier M, Aubry A, Trouillet JL, Bernard M, Chastre J. Usefulness of procalcitonin for the diagnosis of ventilator-associated pneumonia. Intensive Care Med. 2008 Aug;34(8):1434-40. doi: 10.1007/s00134-008-1112-x. Epub 2008 Apr 18.
Linssen CF, Bekers O, Drent M, Jacobs JA. C-reactive protein and procalcitonin concentrations in bronchoalveolar lavage fluid as a predictor of ventilator-associated pneumonia. Ann Clin Biochem. 2008 May;45(Pt 3):293-8. doi: 10.1258/acb.2007.007133.
Flanagan PG, Jackson SK, Findlay G. Diagnosis of gram negative, ventilator associated pneumonia by assaying endotoxin in bronchial lavage fluid. J Clin Pathol. 2001 Feb;54(2):107-10. doi: 10.1136/jcp.54.2.107.
el-Ebiary M, Torres A, Gonzalez J, Martos A, Puig de la Bellacasa J, Ferrer M, Rodriguez-Roisin R. Use of elastin fibre detection in the diagnosis of ventilator associated pneumonia. Thorax. 1995 Jan;50(1):14-7. doi: 10.1136/thx.50.1.14.
Lassalle P, Molet S, Janin A, Heyden JV, Tavernier J, Fiers W, Devos R, Tonnel AB. ESM-1 is a novel human endothelial cell-specific molecule expressed in lung and regulated by cytokines. J Biol Chem. 1996 Aug 23;271(34):20458-64. doi: 10.1074/jbc.271.34.20458.
Tang L, Zhao Y, Wang D, Deng W, Li C, Li Q, Huang S, Shu C. Endocan levels in peripheral blood predict outcomes of acute respiratory distress syndrome. Mediators Inflamm. 2014;2014:625180. doi: 10.1155/2014/625180. Epub 2014 Jul 16.
Kupeli I, Salcan S, Kuzucu M, Kuyrukluyildiz U. Can endocan be a new biomarker in ventilator-associated pneumonia? Kaohsiung J Med Sci. 2018 Dec;34(12):689-694. doi: 10.1016/j.kjms.2018.07.002. Epub 2018 Aug 9.
Other Identifiers
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ERZINCAN UNIVERSITY 3
Identifier Type: -
Identifier Source: org_study_id
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