Identification of Biomarkers in the Legal Medical Skin Wounds

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-09-01

Study Completion Date

2020-03-01

Brief Summary

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Identify the cytokine or combination of cytokines, with the best diagnostic performance to characterize the vital nature of a skin wound in the body.

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Detailed Description

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Determining the vitality of skin wounds, that is to say their antemortem character, is an important issue in forensic pathology. The only criterion vitality currently recognized (but whose diagnostic performance remains limited) is the microscopic demonstration of an inflammatory infiltrate of neutrophils. The search for more reliable diagnostic biomarkers is required. By their early expression of the injury site, inflammatory cytokines are potential candidates and their quantification in injured skin could optimize the diagnosis of vitality injury.

The objective is to identify the cytokine or combination of cytokines, with the best diagnostic performance to characterize the vital nature of a skin wound in the body.

Conditions

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Legal Medical Skin Wounds

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Interventions

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autopsy

At autopsy achieving adequate sampling of lesions and healthy skin

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Adult died 18 years or more
* Having at least one recent ante-mortem skin wound (occurring less than 4 hours prior to death)
* Hours of death and the establishment of the ante-mortem wound known (date, hours and minutes)