The Effect of Autologous Stromal Vascular Fractions on Skin Regeneration
NCT ID: NCT03189628
Last Updated: 2017-06-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
UNKNOWN
PHASE1/PHASE2
30 participants
INTERVENTIONAL
2017-03-13
2018-03-13
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
The Improving Effect of Autologous Stromal Vascular Fraction (SVF) in Adipose Tissue on Skin Grafting
NCT02546882
The Effect of Stromal Vascular Fraction Transplantation on the Regeneration of Expanded Skin
NCT07114692
Skin Dermal Regeneration After Stromal Vascular Fraction Transplantation
NCT06439459
Evaluation of the Effect of Autologous Fat and SVF Transplantation in Promoting Mechanical-stretch Induced in Vivo Skin Regeneration
NCT02336997
Autologous Adipose Stem Cell Assisted Skin Graft
NCT04532593
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
The clinical trial will concentrate on the therapeutic effect of SVF after facial injection. After 1, 4, 8, 12, 24 and 48 weeks of treatment, a comprehensive examination of the facial skin was performed to assess the effect of the SVF. Skin texture, thickness and colour will be observed to evaluate the effect of SVF on skin regeneration
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
stromal vascular fraction
Transplantation of resuspended SVF
stromal vascular fraction
The adipose tissue(no less than 40ml) in abdomen will be harvested and digested at 37 °C for (45-60) min with (0.125-1.5)mg/ml collagenase . After filtration and centrifugation at the speed of (700-1500)g, mature adipocytes are separated from the cell pellet. The pellet then is treated with saline twice to remove cell fragment and rudimental collagenase . The harvested pellet is stromal vascular fraction (SVF) The SVF was resuspended in 1 ml saline and transplanted for 3 area including the forehead、palpebra inferior and crow's-feet.
saline
1 ml saline without cells will be used as placebo.
Saline
1 ml saline was injected for 3 area including the forehead、palpebra inferior and crow's-feet.
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
stromal vascular fraction
The adipose tissue(no less than 40ml) in abdomen will be harvested and digested at 37 °C for (45-60) min with (0.125-1.5)mg/ml collagenase . After filtration and centrifugation at the speed of (700-1500)g, mature adipocytes are separated from the cell pellet. The pellet then is treated with saline twice to remove cell fragment and rudimental collagenase . The harvested pellet is stromal vascular fraction (SVF) The SVF was resuspended in 1 ml saline and transplanted for 3 area including the forehead、palpebra inferior and crow's-feet.
Saline
1 ml saline was injected for 3 area including the forehead、palpebra inferior and crow's-feet.
Other Intervention Names
Discover alternative or legacy names that may be used to describe the listed interventions across different sources.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* No other facial plastic surgery or cosmetic surgery was performed during the study period (frontal, temporal, and lower eyelid).
* Intends to undergo facial anti-aging treatment with SVF
Exclusion Criteria
* Evidence of infection, ischemia, ulcer or other pathological changes within the targeting area which defined as not suitable for SVF treatment; or history of delayed healing, radiational therapy.
* Significant renal, cardiovascular, hepatic and psychiatric diseases.
* Significant medical diseases or infection (including but not limited to the carrier of hepatitis B virus or HIV).
* Used external medication on the targeting area within 4 weeks.
* Skin invasive treatment including laser on the targeting area within 6 months.
* Hyaluronic acid injection on the targeting area within 12 months.
* Botulinum toxin injection on the targeting area within 6 months.
* History of any hematological disease, including leukopenia , thrombocytopenia, or thrombocytosis.
* Evidence of malignant diseases or unwillingness to participate.
18 Years
65 Years
ALL
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Shanghai Jiao Tong University School of Medicine
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Qing-FengLi Li,MD
MD, PhD, Professor, Head of Departement of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Li Qingfeng, MD; PhD
Role: STUDY_CHAIR
Shanghai Ninth People's Hospital, Affliated to Shanghai Jiao Tong University School of Medicine
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Shanghai Ninth People's Hospital, Affliated to Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China
Countries
Review the countries where the study has at least one active or historical site.
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Facility Contacts
Find local site contact details for specific facilities participating in the trial.
References
Explore related publications, articles, or registry entries linked to this study.
Qin J, Cheng C, Huang RL, He J, Zhou S, Tan PC, Zhang T, Fang B, Li Q, Xie Y. Isolation of the Stromal Vascular Fraction Using a New Protocol with All Clinical-Grade Drugs: From Basic Study to Clinical Application. Aesthetic Plast Surg. 2024 Nov;48(22):4702-4711. doi: 10.1007/s00266-024-04221-9. Epub 2024 Jul 10.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
2016-261-T196
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.