Study of the Cutaneous Reinnervation After Burn

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

6 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-08-31

Study Completion Date

2016-09-30

Brief Summary

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The aim of this study is to understand why the regeneration of the cutaneous sensory nerve fibers is poor in post-burn scar.

The presence or the lack of several molecular factors known to regulate neuronal cell development will be evaluate and compared within biopsies from healthy skin and post-burn scar.

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Detailed Description

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Conditions

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Post-burn Innervation

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Blinding Strategy

NONE

Study Groups

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Skin biopsy

On the same patient, a biopsy of post-burn scar is removed. A second one is removed from healthy skin.

Group Type OTHER

Skin biopsy

Intervention Type PROCEDURE

2 biopsies are done on the same patient : 20 cutaneous biopsies from post-burn scar and from healthy skin

Interventions

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Skin biopsy

2 biopsies are done on the same patient : 20 cutaneous biopsies from post-burn scar and from healthy skin

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Major patients
* At least one year back deep burn (2nd and 3rd degrees), and allowing the comparison between the post-burn scar dermatome and the healthy opposite dermatome
* Patients always followed in the service of Plastic surgery of the hospital of Brest
* Informed consent and paper of the patient after information of the objective of the study and the protocol
* Analog Visual scales for pain and/or pruritus (EVA): greater than or equal to 3
* Simple Verbal scales for the pain and/or the pruritus ( EVS): pain / pruritus moderated to intense
* Membership to the Social Security

Exclusion Criteria

* Allergy to xylocaine
* Non-Caucasian patients
* Treatments having an effect on the pain and/or the pruritus
* Sun or UV exposure several days preceding or following the biopsies

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No