Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
12 participants
INTERVENTIONAL
2013-10-31
2014-12-31
Brief Summary
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Twelve healthy subjects, on a stable diet, in a randomized-crossover fashion, received either a 50 g glucose load (control) or one of these breakfast:
B1: milk (125ml) and cereals (30g); B2: milk (220ml), apple (200g) and cream chocolate filled sponge cake (30g); B3: milk (125ml), bread (50g), apple (150g) and hazelnut cream chocolate (15g). Prior and upon completion of each tolerance test, an EEG was performed to measure frontal P300-evoked potentials.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
HEALTH_SERVICES_RESEARCH
NONE
Study Groups
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Glucose
EEG\_pre + Oral glucose tolerance test (50-g OGTT) + EEG\_post
Glucose
50g of glucose dissolved in 250 to 300ml of water was drunk. Prior and upon completion of each glucose tolerance test, an EEG was performed.
EEG_pre
Electroencephalography (EEG) was performed prior each tolerance test to assess frontal P300-evoked potentials
EEG_post
Electroencephalography (EEG) was performed upon completion of each tolerance test to assess frontal P300-evoked potentials
Milk + Cereals
EEG\_pre + B1: milk (125ml) and cereals (30g) + EEG\_post
Milk & Cereals
A breakfast (B1) including a glass of milk (125ml) and 30 g-corn flakes was consumed. Prior and upon completion of each tolerance test, an EEG was performed
Milk, apple & snack
A breakfast (B2) including a glass of milk (220ml), an apple (200g), a cream chocolate filled sponge cake (30g) was consumed. Prior and upon completion of each meal tolerance test, an EEG was performed.
EEG_pre
Electroencephalography (EEG) was performed prior each tolerance test to assess frontal P300-evoked potentials
EEG_post
Electroencephalography (EEG) was performed upon completion of each tolerance test to assess frontal P300-evoked potentials
Milk + Apple + Snack
EEG\_pre + B2: milk (220ml), apple (200g) and cream chocolate filled sponge cake (30g) + EEG\_post
Milk & Cereals
A breakfast (B1) including a glass of milk (125ml) and 30 g-corn flakes was consumed. Prior and upon completion of each tolerance test, an EEG was performed
Milk, apple & bread w/ cream
A breakfast (B3) including a glass of milk (125ml), an apple (150g), bread (50g, hazelnut chocolate cream (15g) was consumed. Prior and upon completion of each meal tolerance test, an EEG was performed.
EEG_pre
Electroencephalography (EEG) was performed prior each tolerance test to assess frontal P300-evoked potentials
EEG_post
Electroencephalography (EEG) was performed upon completion of each tolerance test to assess frontal P300-evoked potentials
Milk + Apple + Bread w/ cream
EEG\_pre + B3: milk (125ml), apple (150g), and bread (50g) with hazelnut chocolate cream (15g) + EEG\_post
Milk & Cereals
A breakfast (B1) including a glass of milk (125ml) and 30 g-corn flakes was consumed. Prior and upon completion of each tolerance test, an EEG was performed
Milk, apple & bread w/ cream
A breakfast (B3) including a glass of milk (125ml), an apple (150g), bread (50g, hazelnut chocolate cream (15g) was consumed. Prior and upon completion of each meal tolerance test, an EEG was performed.
EEG_pre
Electroencephalography (EEG) was performed prior each tolerance test to assess frontal P300-evoked potentials
EEG_post
Electroencephalography (EEG) was performed upon completion of each tolerance test to assess frontal P300-evoked potentials
Interventions
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Glucose
50g of glucose dissolved in 250 to 300ml of water was drunk. Prior and upon completion of each glucose tolerance test, an EEG was performed.
Milk & Cereals
A breakfast (B1) including a glass of milk (125ml) and 30 g-corn flakes was consumed. Prior and upon completion of each tolerance test, an EEG was performed
Milk, apple & snack
A breakfast (B2) including a glass of milk (220ml), an apple (200g), a cream chocolate filled sponge cake (30g) was consumed. Prior and upon completion of each meal tolerance test, an EEG was performed.
Milk, apple & bread w/ cream
A breakfast (B3) including a glass of milk (125ml), an apple (150g), bread (50g, hazelnut chocolate cream (15g) was consumed. Prior and upon completion of each meal tolerance test, an EEG was performed.
EEG_pre
Electroencephalography (EEG) was performed prior each tolerance test to assess frontal P300-evoked potentials
EEG_post
Electroencephalography (EEG) was performed upon completion of each tolerance test to assess frontal P300-evoked potentials
Eligibility Criteria
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Inclusion Criteria
* normal glucose tolerance
* stable diet
Exclusion Criteria
* impaired glucose tolerance
* dyslipidemia
* metabolic syndrome
18 Years
40 Years
ALL
Yes
Sponsors
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Soremartec Italia S.r.l.
UNKNOWN
Ospedale San Donato
OTHER
Responsible Party
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Anna Ferrulli
MD
Locations
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San Donato Hospital
San Donato Milanese, MI, Italy
Countries
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References
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Barclay AW, Brand-Miller JC, Wolever TM. Glycemic index, glycemic load, and glycemic response are not the same. Diabetes Care. 2005 Jul;28(7):1839-40. doi: 10.2337/diacare.28.7.1839. No abstract available.
Franz MJ. The glycemic index: not the most effective nutrition therapy intervention. Diabetes Care. 2003 Aug;26(8):2466-8. doi: 10.2337/diacare.26.8.2466. No abstract available.
Esposito K, Giugliano D. Low-glycemic load diet and resting energy expenditure. JAMA. 2005 Mar 9;293(10):1189; auhor reply 1189-90. doi: 10.1001/jama.293.10.1189-a. No abstract available.
Benedini S, Codella R, Caumo A, Marangoni F, Luzi L. Different circulating ghrelin responses to isoglucidic snack food in healthy individuals. Horm Metab Res. 2011 Feb;43(2):135-40. doi: 10.1055/s-0030-1269900. Epub 2011 Jan 10.
Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes. 2001 Aug;50(8):1714-9. doi: 10.2337/diabetes.50.8.1714.
Other Identifiers
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Colazioni/4
Identifier Type: -
Identifier Source: org_study_id
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