Ordered Eating and Acute Exercise

NCT ID: NCT06242015

Last Updated: 2025-08-01

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 23 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-02-06
• Study Completion Date: 2024-07-30

Brief Summary

There is well documented evidence that ingesting dietary carbohydrate in large amounts tends to increase postprandial glucose. In healthy populations, this is not necessarily a problem, but continuous exposure to high levels of glucose-hyperglycemia-is a defining characteristic and risk factor for type 2 diabetes mellitus. Consuming a carbohydrate-rich food as the final food in a meal sequence has been shown to significantly reduce postprandial glucose excursions in both diabetes patients and in healthy controls. The exact mechanisms behind this phenomenon are not well understood, but one proposed course is simply that the vegetable and protein already being digested slows the rate of glucose rise.

Despite the findings, little-to-no research has examined how manipulating the order of foods in a meal impacts subsequent exercise responses. In this experimental crossover study, each participant will undergo two acute feeding conditions (carbohydrate-rich foods first vs. last in a meal), which will be followed by exercise 60 minutes later. We will observe the effects of meal order on postprandial glucose, substrate/fuel utilization, and subjective perceptions at rest and during 30 minutes of exercise.

Conditions

Glucose Metabolism Disorders; Hunger

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Carbohydrate-first meal

Group Type: EXPERIMENTAL

Carbohydrate-first meal

Intervention Type: OTHER

Rice (150 grams) eaten first, followed by broccoli (150 grams) and chicken (100 grams)

Carbohydrate-last meal

Group Type: EXPERIMENTAL

Carbohydrate-last meal

Intervention Type: OTHER

Broccoli (150 grams) and chicken (100 grams) eaten first, followed by rice (150 grams)

Interventions

Carbohydrate-first meal

Rice (150 grams) eaten first, followed by broccoli (150 grams) and chicken (100 grams)

Intervention Type: OTHER

Carbohydrate-last meal

Broccoli (150 grams) and chicken (100 grams) eaten first, followed by rice (150 grams)

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Currently physically active (scheduled exercise at least three days per week for 30 minutes each time over the last three months)
• Ability to perform moderate-to-high intensity running for at least 30 minutes

Exclusion Criteria

• Any allergy or other condition that would prohibit the consumption of poultry, rice, or broccoli
• Any injury or disease (cardiovascular disease, diabetes, pulmonary disease except controlled asthma) precluding physical exercise
• Currently pregnant
• Implanted electrical devices such as a pacemaker.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Old Dominion University

OTHER

Sponsor Role: lead

Responsible Party

Patrick Wilson, PhD

Associate Professor of Exercise Science

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Patrick Wilson

Role: PRINCIPAL_INVESTIGATOR

Old Dominion University

Locations

ODU Human Performance Laboratory

Norfolk, Virginia, United States

Countries

United States

Other Identifiers

24-003

Identifier Type: -

Identifier Source: org_study_id