Neuronal Excitability of HCN1 Channel Mutations in Dravet Syndrome

NCT ID: NCT02896608

Last Updated: 2023-02-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

92 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-10-29

Study Completion Date

2019-10-16

Brief Summary

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This study addresses the changes in the axonal excitability parameters. It will compare these changes in patients with early infantile epileptic encephalopathy with HCN1 channel mutation and in control patients, with and without epilepsy.

Detailed Description

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Conditions

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Dravet Syndrome

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Dravet syndrome - HCN1 channel mutation

early infantile epileptic encephalopathy with HCN1 channel mutation

measure of neuronal excitability

Intervention Type DEVICE

control with epilepsy

measure of neuronal excitability

Intervention Type DEVICE

control without epilepsy

measure of neuronal excitability

Intervention Type DEVICE

Interventions

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measure of neuronal excitability

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* early infantile epileptic encephalopathy with HCN1 channel mutation
* control patients with no neurologic pathology (age, gender and body temperature matched)
* epileptic patients (age, gender and body temperature matched)

Exclusion Criteria

* pregnant or breast feeding patient
Minimum Eligible Age

15 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Fondation Ophtalmologique Adolphe de Rothschild

NETWORK

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Fondation Ophtalmologique Adolphe de Rothschild

Paris, , France

Site Status

Countries

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France

Other Identifiers

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AGN_2015_11

Identifier Type: -

Identifier Source: org_study_id

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