Impact of Thermocoagulation During Invasive EEG Monitoring in Children With Focal Drug-resistant Epilepsies

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-12-31

Study Completion Date

2024-05-28

Brief Summary

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When focal epilepsies become drug-resistant, it could be eligible for cortical surgical resection. Therefore, an invasive EEG monitoring with depth electrodes is often needed during presurgical evaluation. Some of these children can have access to thermocoagulation inside the ictal onset zone, at the end of the monitoring and before to remove the electrodes. These thermocoagulations can disorganize the epileptogenic network thanks to millimetric cortical lesions around the electrodes. The aim is to stop or at least, to reduce the seizure frequency for few weeks or months. This could be a benefit for the child, and also a confirmation of the ictal onset zone and guide the surgeon. This technique is currently used in adult population for years, but remains very rare in children.

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Detailed Description

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Conditions

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Epilepsy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Thermocoagulation

Group Type EXPERIMENTAL

Thermocoagulation

Intervention Type PROCEDURE

Thermocoagulation During pre-surgical Invasive EEG Monitoring

Interventions

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Thermocoagulation

Thermocoagulation During pre-surgical Invasive EEG Monitoring

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* age 18 month to 17 years old
* focal drug-resistant epilepsy
* small size lesion (1 or 2 gyri) or cryptogenic epilepsy
* indication for EEG monitoring with depth electrodes during presurgical evaluation

Exclusion Criteria

* formal contraindication to surgery or anaesthesia
* functional area or potentially large epileptic area
* refusal to participate in the study
* no health insurance coverage

Minimum Eligible Age

18 Months

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No