Biological Markers Evaluation of Accelerated Tooth Movement
NCT ID: NCT02887547
Last Updated: 2019-07-01
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
25 participants
INTERVENTIONAL
2016-08-31
2020-05-31
Brief Summary
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Detailed Description
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Orthodontic records done in two times, initial and preoperative; Gingival Crevicular Fluid samples will be collected using periopapers in 7 times (1, 2, 7, 14, 28 days and after space closure- end of orthodontic treatment movement activation).
Flapless cortical perforations will be made in ATMT Group after dental extraction. Surgical protocol will be flapless to preserve periodontal health.
After extraction space closure, results will be assessed by clinical effects with biological markers levels:
CCL3/MIP-1 alpha, CCL5/RANTES, CXCL8/IL8, IL-1 alpha, IL-1 beta, IL6, TNF-alpha, TRANCE/RANK L, OCN OPG IL-10 VEGF TGF-ℬ
Those biomarkers levels will be performed using ELISA Assays. After collecting data, the results will be statistically analyzed using Shapiro-Wilk and, posteriorly, T-student or Wilcoxon.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
DIAGNOSTIC
NONE
Study Groups
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Control
Control group, with traditional orthodontic mechanics for anterior retraction. Crevicular fluid will be collected during anterior retraction mechanics to identified biomarkers in the inflammatory process
No interventions assigned to this group
Acceleration
Group with micro-osteoperforation for accelerated tooth movement during anterior retraction, Crevicular fluid will be collected during anterior retraction mechanics to identified biomarkers in the inflammatory process
micro-osteoperforation
Interventions
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micro-osteoperforation
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Indication for orthognathic surgery
* Tooth extraction indication for orthodontic treatment
* Do not smoke
* Periodontal and teeth healthy
* Do not use bisphosphonates or corticosteroids
Exclusion Criteria
* Cleft lip and palate
* Craniofacial syndrome
* Mental disorder
* Metabolic diseases
18 Years
40 Years
ALL
Yes
Sponsors
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University of Sao Paulo
OTHER
Responsible Party
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LIANA FATTORI ABATI
MS, PhD
Principal Investigators
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Liana Fattori, MS PhD
Role: PRINCIPAL_INVESTIGATOR
Phd candidate
Jose Rino Neto
Role: STUDY_CHAIR
University of Sao Paulo
Other Identifiers
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Fattori2
Identifier Type: -
Identifier Source: org_study_id
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