Tachykinin and Kisspeptin Expression in Human Granulosa and Cumulus Cells
NCT ID: NCT02877992
Last Updated: 2020-02-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
236 participants
INTERVENTIONAL
2014-01-31
2019-07-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Donors
Oocyte donors without infertility problems
Ovarian puncture
Donors and patients are subjected to ovarian puncture as part of their donation procedure or IVF treatment. Oocyte are retrieved in this procedure along with granulosa and cumulus cells. Donors and patients sign an informed consent in order to donate their granulosa and cumulus cells for the study.
PCOS
Patients with Polycystic Ovary Syndrome (PCOS) according to Rotterdam criteria
Ovarian puncture
Donors and patients are subjected to ovarian puncture as part of their donation procedure or IVF treatment. Oocyte are retrieved in this procedure along with granulosa and cumulus cells. Donors and patients sign an informed consent in order to donate their granulosa and cumulus cells for the study.
Endometriosis
Patients with endometriosis (I-IV)
Ovarian puncture
Donors and patients are subjected to ovarian puncture as part of their donation procedure or IVF treatment. Oocyte are retrieved in this procedure along with granulosa and cumulus cells. Donors and patients sign an informed consent in order to donate their granulosa and cumulus cells for the study.
Age
Patients with advanced maternal age (38 years or more)
Ovarian puncture
Donors and patients are subjected to ovarian puncture as part of their donation procedure or IVF treatment. Oocyte are retrieved in this procedure along with granulosa and cumulus cells. Donors and patients sign an informed consent in order to donate their granulosa and cumulus cells for the study.
Low ovarian response
Patients with low ovarian response according to Bologna criteria
Ovarian puncture
Donors and patients are subjected to ovarian puncture as part of their donation procedure or IVF treatment. Oocyte are retrieved in this procedure along with granulosa and cumulus cells. Donors and patients sign an informed consent in order to donate their granulosa and cumulus cells for the study.
Interventions
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Ovarian puncture
Donors and patients are subjected to ovarian puncture as part of their donation procedure or IVF treatment. Oocyte are retrieved in this procedure along with granulosa and cumulus cells. Donors and patients sign an informed consent in order to donate their granulosa and cumulus cells for the study.
Eligibility Criteria
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Inclusion Criteria
* Normal caryotype
* Normal psychological test
* Age between 18 and 45 years
* One of the following etiologies:
* Patient with PCOS according to Rotterdam Criteria or
* Patients with endometriosis stage I-IV or
* Patients with low ovarian response according to Bologna criteria or
* Patients with advances maternal age (between 38 and 45 years)
Exclusion Criteria
* Beta-thalassemia
* Cystic fibrosis
* Human immunodeficiency virus (HIV), Hepatitis B virus (HBV), Hepatitis C virus (HCV)
2. Infertility patients
18 Years
45 Years
FEMALE
Yes
Sponsors
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Vida Recoletas Sevilla
OTHER
Responsible Party
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Manuel Fernandez-Sanchez
Dr
Locations
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Instituto de Investigaciones Químicas
Seville, , Spain
IVI Sevilla
Seville, , Spain
Countries
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References
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Garcia-Ortega J, Pinto FM, Fernandez-Sanchez M, Prados N, Cejudo-Roman A, Almeida TA, Hernandez M, Romero M, Tena-Sempere M, Candenas L. Expression of neurokinin B/NK3 receptor and kisspeptin/KISS1 receptor in human granulosa cells. Hum Reprod. 2014 Dec;29(12):2736-46. doi: 10.1093/humrep/deu247. Epub 2014 Oct 14.
Garcia-Ortega J, Pinto FM, Prados N, Bello AR, Almeida TA, Fernandez-Sanchez M, Candenas L. Expression of Tachykinins and Tachykinin Receptors and Interaction with Kisspeptin in Human Granulosa and Cumulus Cells. Biol Reprod. 2016 Jun;94(6):124. doi: 10.1095/biolreprod.116.139881. Epub 2016 May 4.
Other Identifiers
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IVISEVILLA
Identifier Type: -
Identifier Source: org_study_id
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