A Model for Healthy Aging: Moscow Centenarians (AGE-100)

NCT ID: NCT02876809

Last Updated: 2021-03-23

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2016-10-31
• Study Completion Date: 2021-03-31

Brief Summary

This study evaluates the associations between biomarkers of ageing, comprehensive geriatric status, telomere length and progerin level, the composition of the gut microbiota, 16sRNA metagenome sequencing in Moscow centenarians.

Detailed Description

The global average life expectancy and the average age of the population are growing steadily along with the age-related diseases. The same trend is also observed in our country. Although, maximum life span in Russia decreases. E.g., the number of centenarians in Moscow decreased by 244 persons from 2013 to 2014. There were about 400 centenarians in Moscow in 2014. That is about 3.3 per 100 000 population. In the US, this figure is about 10-20, and there are 50 centenarians per 100 000 population in the Okinawa region, Japan. The rate of ageing varies substantially, a prime example of this is the centenarians population. These people break conventional stereotypes about aging. Chronic diseases in centenarians are postponed. They are more active, they work longer, they can better tolerate stressful situations. Scientists all over the world are trying to find the secret of their longevity. Studies on the medical and social aspects of centenarian longevity are actively carried out in the US, Europe, Japan, Australia. In Russia studies were carried out in St. Petersburg, Western and Eastern Siberia. According to the New England Centenarian Study, the supercentenarians (persons who have lived more than 110 years) life span is actually equal to the healthy span without serious illnesses. The aim of research is to study features of social status, lifestyle, habits, clinical status, blood chemistry, the amount of progerin, genome, composition of the gut microbiota in Moscow centenarians in order to create a model of healthy aging. In this study a comprehensive analysis of the longevity phenomenon of one hundred centenarians from Moscow and the Moscow region planning to be conducted. Analyzing of anamnesis vitae, medical, social, neuro-cognitive, and genetic features is planning. Each study participant will undergo a comprehensive geriatric assessment, including examination by the neurologist, an assessment of cognitive status,psychogeriatric consultation with the assessment of self-perceptions of aging and depression assessment by using the geriatric depression scale, neuropsychological testing using the Montreal Cognitive Assessment (MoCA), verbal recognition memory 12 word test, clock-drawing test.Telomere length and progerin level in buffy coat layer evaluation, 16sRNA metagenome sequencing, and nuclear magnetic resonance spectroscopy for qualitative and quantitative analysis of metabolites in blood serum, will be done in all participants. This study will take the science closer to the goal of identifying the patterns of "healthy" aging.

Conditions

Aging

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: CROSS_SECTIONAL

Eligibility Criteria

Inclusion Criteria

age over 90 years

-

Exclusion Criteria

age under 90 years refusal to participate in the study

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• Minimum Eligible Age: 90 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Pirogov Russian National Research Medical University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Olga N. Tkacheva, Professor

Role: PRINCIPAL_INVESTIGATOR

Russian Gerontology Clinical Research Center

Locations

Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Russian Gerontology Clinical Research Center

Moscow, , Russia

Countries

Russia

Related Links

http://www.ncbi.nlm.nih.gov/pubmed/?term=Collino+S%2C+Montoliu+I%2C+Martin+FP%2C+Scherer+M%2C+Mari+D%2C+Salvioli+S%2C+et+al.+Metabolic+signatures+of+extreme+longevity+in+northern+Italian+centenarians+reveal+a+complex+remodeling+of+lipids%2C+amino+acids%2C+and+gut+microbiota+metabolism.

This novel approach support the hypothesis that a complex remodeling of lipid, amino acid metabolism, and of gut microbiota functionality are key regulatory processes marking exceptional longevity in humans.

http://www.ncbi.nlm.nih.gov/pubmed/?term=Ailshire+JA%2C+Beltran-Sanchez+H%2C+Crimmins+EM.+Becoming+centenarians%3A+disease+and+functioning+trajectories+of+older+US+Adults+as+they+survive+to+100.+J+Gerontol+A+Biol+Sci+Med+Sci

While some centenarians have poor health and functioning upon reaching age 100, others are able to achieve exceptional longevity in relatively good health and without loss of functioning.

http://www.ncbi.nlm.nih.gov/pubmed/?term=Franzke+B%2C+Neubauer+O%2C+Wagner+KH.+Super+DNAging-New+insights+into+DNA+integrity%2C+genome+stability+and+telomeres+in+the+oldest+old.+Mutat+Res+Rev+Mutat+Res

Available data indicate improved DNA repair and antioxidant defense mechanisms in "super old" humans, which are comparable with much younger cohorts.

http://www.ncbi.nlm.nih.gov/pubmed/?term=Gentilini+D%2C+Mari+D%2C+Castaldi+D%2C+Remondini+D%2C+Ogliari+G%2C+Ostan+R%2C+et+al.+Role+of+epigenetics+in+human+aging+and+longevity%3A+genome-wide+DNA+methylation+profile+in+centenarians+and+centenarians%27+offspring

Results suggest that a better preservation of DNA methylation status, a slower cell growing/metabolism, and a better control in signal transmission through epigenetic mechanisms may be involved in the process of human longevity.

Other Identifiers

MCA-100

Identifier Type: -

Identifier Source: org_study_id