The Inspire Bio-resource Research Platform for Healthy Aging INSPIRE Platform

NCT ID: NCT04224038

Last Updated: 2023-11-21

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 1000 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2019-10-16
• Study Completion Date: 2033-10-31

Brief Summary

Since aging is a systemic (not organ-specific) phenomenon, the main objective of Inspire Bio-resource Research Platform for Healthy Aging is to build a comprehensive research platform gathering biological, clinical (including imaging) and digital resources that will be explored to identify robust (set of) markers of aging, age-related diseases and IC evolution. The Inspire Platform will gather data and biospecimens from subjects of different ages (from 30 years or over - no upper limit for age) and functional capacity levels (from robust to frail to disabled) over 10 years.

Detailed Description

This is a 10-year observational study. The study will be performed in Occitania Region. Once a year, a complete data collection will be performed in the Gerontopole of Toulouse, in participants' home and health centers by the Gerontopole mobile research team, and in selected Gerontopole's collaborating centers in Occitania.

Between yearly waves of data collection, participants will have their intrinsic capacity domains monitored (with or without the help of a caregiver) each 4-month through the use of either an app developed in collaboration with World Health Organization (WHO) or a web platform; or through a phone call by a clinical/research nurse. For the first self-monitoring of IC at four months, all participants will be contacted by a research/clinical nurse by phone; this call will inform about how participants measured their capacity and/or help them to do it. After this first 4-month phone call, participants capable of correctly self-monitoring their IC through the app will no longer be systematically contacted by phone. Once IC declines are confirmed, participants will have a thorough clinical assessment and blood sampling; such information will allow us to investigate the response of markers of aging at the time declines are detected. Those needing usual care, will be followed according to WHO framework recommendations proposed for Integrated Care for Older Adults (ICOPE).

Conditions

Biological Aging

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Interventions

The Inspire Bio-resource Research Platform for Healthy Aging

Several follow-up visits will be undertaken during the 10-year time frame of this project. Some of these visits are not regularly scheduled and will be conditioned by the remote monitoring of intrinsic capacity (IC) and the onset of other major clinical conditions. Other visits correspond to the regularly scheduled (yearly or every two years (biannual visits), depending on the outcome measures) waves of data collection.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Aged 30 years-old or over;
• Both sexes
• Affiliated to a social security scheme

Exclusion Criteria

• severe disease compromising life expectancy at 5 years;
• Deprived of their liberty by administrative or judicial decision, or under guardianship

• Minimum Eligible Age: 30 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

European Regional Development Fund

OTHER

Sponsor Role: collaborator

University Hospital, Toulouse

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Bruno VELLAS, MD

Role: PRINCIPAL_INVESTIGATOR

University Hospital of Toulouse

Locations

University Hospital Toulouse

Toulouse, , France

Site Status: RECRUITING

Countries

France

Central Contacts

Bruno VELLAS, MD

Role: CONTACT

vellas.b@chu-toulouse.fr

5 61 77 70 47 ext. +33

Sophie GUYONNET, PhD

Role: CONTACT

guyonnet.s@chu-toulouse.fr

5 61 77 70 43 ext. +33

Facility Contacts

Bruno Vellas, MD

Role: primary

vellas.b@chu-toulouse.fr

05.61.77.70.47 ext. 33

Sophie Guyonnet

Role: backup

guyonnet.s@chu-toulouse.fr

5 61 77 70 43 ext. 33

Other Identifiers

RC31/19/0236

Identifier Type: -

Identifier Source: org_study_id