Locally Applied Pressure-induced Vasodilatation

NCT ID: NCT02861924

Last Updated: 2019-11-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

45 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-10-11

Study Completion Date

2019-03-31

Brief Summary

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Measure microcirculatory responses after localized ischemia obtained by local application of pressure (laser speckle).

Detailed Description

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Measure microcirculatory responses after localized ischemia obtained by local application of pressure (laser speckle). The purpose of this study is to perform measurements of the methodological points made.

The study will investigate :

* The effect of the duration and intensity of the pressure
* The reproducibility of measurements
* The correlation with ischemic hyperemia post

Conditions

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Vascular Diseases

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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microcirculatory responses

Measure microcirculatory responses after localized ischemia obtained by local application of pressure (laser speckle).

A pressure is applied to the subject's arm. this causes a localized ischemia. the measures responses to this ischemia will be made by the imager speckle (LSCI) give the microvascular perfusion data.

Group Type EXPERIMENTAL

microcirculatory responses

Intervention Type OTHER

The effect of the duration and intensity of the pressure; reproducibility and correlation with ischemic hyperemia post.

measurements are made with the Imager SPECKLE imager (LSCI) give the microvascular perfusion data in arbitrary units called perfusion units (UP).

Interventions

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microcirculatory responses

The effect of the duration and intensity of the pressure; reproducibility and correlation with ischemic hyperemia post.

measurements are made with the Imager SPECKLE imager (LSCI) give the microvascular perfusion data in arbitrary units called perfusion units (UP).

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* subjects without vascular pathology

Exclusion Criteria

* pregnancy
* allergy tape
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Angers

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pierre ABRAHAM, professor

Role: PRINCIPAL_INVESTIGATOR

UH ANGERS

Locations

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CHU Angers

Angers, , France

Site Status

Countries

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France

References

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Henni S, Hersant J, Loufrani L, Duval G, Humeau-Heurtier A; SIMS Group; Riou J, Abraham P; SOCOS Group. Painless local pressure application to test microvascular reactivity to ischemia. Microvasc Res. 2019 Mar;122:13-21. doi: 10.1016/j.mvr.2018.10.013. Epub 2018 Nov 3.

Reference Type DERIVED
PMID: 30399363 (View on PubMed)

Other Identifiers

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2016-A00609-42

Identifier Type: -

Identifier Source: org_study_id

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