Ursodeoxycholic Acid for Rhegmatogenous Retinal Detachment

NCT ID: NCT02841306

Last Updated: 2019-04-25

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 26 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-07-31
• Study Completion Date: 2017-09-30

Brief Summary

26 patients presenting a rhegmatogenous retinal detachment with more than 4 days of duration will be prospectively included.

A single dose of ursodeoxycholic acid will be administered orally before surgery at different time-points in 22 subjects. Standard surgery will be performed and ocular samples will be collected during the procedure. Ursodeoxycholic acid treatment will be continued in treated patients during 3 months after surgery.

Ocular and serum samples from the 4 untreated patients will serve as negative controls for the determination of UDCA levels.

Detailed Description

Retinal detachments consist in a separation of the neuroretina from the retinal pigment epithelium. The most common form is rhegmatogenous retinal detachment (RRD), which occurs as a result of a full-thickness retinal break and the presence of vitreoretinal tractions. Photoreceptor cell death occurs rapidly after RRD and is the ultimate cause of vision loss in these patients. Reattachment of the retina by a surgical procedure allows a recovery of vision. However, the degree of visual recovery differs among patients, despite successful reattachment. This is mainly related to the preoperative visual acuity level, the presence of a macular detachment and its duration. Predicting factors of worse visual acuity are the height of retinal detachment in the macula and the presence of edema, separation, cyst and undulation at the level of the outer nuclear layer showed by optical coherence tomography (OCT). Most patients usually consult with a RRD already involving the macular area after 3 days or more, leading to a worse visual prognostic even with successful surgery. The need for adjuvant neuroprotective agents is then critical to improve photoreceptor survival, functional recovery and subsequent quality of life in patients affected by RRD.

Tauroursodeoxycholic acid (TUDCA) is the taurine conjugate of ursodeoxycholic acid (UDCA), a secondary bile acid produced by intestinal bacteria. UDCA was approved by the Food and Drug Administration (FDA) for the treatment of cholestatic liver disease. Both UDCA and TUDCA are potent inhibitors of apoptosis, in part by interfering with the upstream mitochondrial pathway of cell death, inhibiting oxygen-radical production, reducing endoplasmic reticulum (ER) stress, and stabilizing the unfolded protein response (UPR). TUDCA has been proposed as anti-apoptotic agent in several neurodegenerative diseases, including amyotrophic lateral sclerosis, Alzheimer's, Parkinson's, and Huntington's diseases.

In certain degenerative retinal disorders, such as retinitis pigmentosa, TUDCA plays an important role in preventing cell death. In an animal model of RRD, systemic treatment by TUDCA has been shown to protect photoreceptors from cell death.

The aim of this study is to determine whether detectable levels of UDCA reach the vitreous cavity when administered orally at different time points before surgery for RRD, and to analyze its ocular safety.

20 patients presenting a rhegmatogenous retinal detachment with more than 4 days of duration will be prospectively included.

A single dose of ursodeoxycholic acid will be administered orally before surgery at different time-points in 16 subjects. Standard surgery will be performed and ocular samples will be collected during the procedure. Ursodeoxycholic acid treatment will be continued in treated patients during 3 months after surgery.

Conditions

Rhegmatogenous Retinal Detachment

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

3-5 hours

Duration between oral UDCA intake and surgery of 3-5 hours.

Group Type: ACTIVE_COMPARATOR

Ursodeoxycholic Acid

Intervention Type: DRUG

6-8 hours

Duration between oral UDCA intake and surgery of 6-8 hours.

Group Type: ACTIVE_COMPARATOR

Ursodeoxycholic Acid

Intervention Type: DRUG

9-12 hours

Duration between oral UDCA intake and surgery of 9-12 hours.

Group Type: ACTIVE_COMPARATOR

Ursodeoxycholic Acid

Intervention Type: DRUG

> 12 hours

Duration between oral UDCA intake and surgery of \>12 hours.

Group Type: ACTIVE_COMPARATOR

Ursodeoxycholic Acid

Intervention Type: DRUG

Control

No medication

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Ursodeoxycholic Acid

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Patients presenting a rhegmatogenous retinal detachment with more than 4 days from symptoms onset.

Exclusion Criteria

• Previous vitrectomy, vitreous bleeding, other associated retinal disease.
• Monophthalmic patients.
• Pregnancy and lactation, peptic ulcer, acute or chronic liver disease, acute infection of the gallbladder and biliary tract, repeated biliary colic, Crohn's disease, ulcerative colitis, or other disease of the small intestine and colon, and hypersensitivity.
• Patients treated by Cholestyramine, Colestipol and Antacids containing aluminum hydroxide or magnesium, Cyclosporine, Ciprofloxacin, Nitrendipine, Dapsone.
• Patients presenting with galactose intolerance, the Lapp lactase deficiency or glucose and galactose malabsorption.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 90 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of Lausanne Hospitals

OTHER

Sponsor Role: collaborator

Emory University

OTHER

Sponsor Role: collaborator

Francine Behar-Cohen

OTHER

Sponsor Role: lead

Responsible Party

Francine Behar-Cohen

Professor

Responsibility Role: SPONSOR_INVESTIGATOR

Locations

University of Lausanne

Lausanne, , Switzerland

Countries

Switzerland

Other Identifiers

2016-00644

Identifier Type: -

Identifier Source: org_study_id