Hypertrophic Cardiomyopathy Pilot Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-09-30

Study Completion Date

2020-09-30

Brief Summary

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This study evaluates mechanisms of arrhythmogenicity in hypertrophic cardiomyopathy, in comparison to patients with well-understood arrhythmogenic substrate (ischemic cardiomyopathy), as well as to individuals free from arrhythmogenic substrate

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Detailed Description

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Conditions

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Hypertrophic Cardiomyopathy Coronary Artery Disease

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Case: Hypertrophic cardiomyopathy

HCM patients at high risk for ventricular arrhythmia

Observational: Arrhythmogenic Substrate

Intervention Type OTHER

Control I: Healthy

Healthy Controls

No interventions assigned to this group

Control II: Post-MI with arrhythmogenic substrate

Ischemic cardiomyopathy patients with documented history of ventricular tachyarrhythmia and left ventricular hypertrophy

Observational: Arrhythmogenic Substrate

Intervention Type OTHER

Control III: VT/VF-free ischemic cardiomyopathy

Ischemic cardiomyopathy patients without ventricular arrhythmia, as proven by non-inducibility and history of freedom from ventricular tachyarrhythmia during at least one ICD generator life

No interventions assigned to this group

Interventions

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Observational: Arrhythmogenic Substrate

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Diagnosed HCM
* Documented history of sustained ventricular tachyarrhythmia or resuscitated sudden cardiac arrest
* Maximal left ventricular wall thickness of \> 30mm
* Extensive fibrosis on cardiac MRI (\>15% of total myocardial volume)
* \>7.5%/5-year risk of sudden cardiac death as determined by HCM risk-SCD