Does the Presence of Preoperative Proteinuria Predict Postoperative Acute Kidney Injury in Obese Patients Undergoing Elective Laparoscopic Surgery?

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

1434 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-06-16

Study Completion Date

2023-02-02

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Acute kidney injury (AKI) is a common, but significant complication after elective surgery which is associated with an increased risk of mortality, major adverse cardiac events, prolonged length of hospital stay, and increased cost per episode of care.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Prognostic Significance of Preoperative Nutritional Status on Postoperative Acute Kidney Injury

NCT06496802

Acute Kidney Injury Pneumonectomy

NOT_YET_RECRUITING

Acute Kidney Injury - Biomarkers in Major Abdominal Surgery

NCT04582747

Acute Kidney Injury

COMPLETED

Preoperative Nutritional Status and Postoperative Acute Kidney Injury

NCT05945940

Postoperative Acute Kidney Injury

COMPLETED

Preoperative Inflammatory Status and Postoperative Acute Kidney Injury

NCT06027476

Postoperative Acute Kidney Injury

COMPLETED

Predictive Nomogram for Postoperative Acute Kidney Injury (AKI) in Elderly Patients Following Liver Resection

NCT04922866

Postoperative Acute Kidney Injury

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Acute kidney injury (AKI) is a common, but significant complication after elective surgery which is associated with an increased risk of mortality, major adverse cardiac events, prolonged length of hospital stay, and increased cost per episode of care. Obese patients are at increased risk of postoperative AKI when compared to normal weight patients; however current methods to assess preoperative renal function in this patient population (such as measurement of serum creatinine and calculation of the estimated glomerular filtration rate) have previously been demonstrated to overestimate their true renal function. , Preoperative proteinuria has previously been determined to be predictive of the development of postoperative AKI in patients of all weights undergoing cardiac surgery. Published reports on the prevalence of proteinuria in obese patients span a wide range: from 8- 43%. The investigators aim to determine the predictive value of preoperative proteinuria on the development of postoperative AKI in patients presenting for elective laparoscopic bariatric surgery at NYULMC. The investigators hypothesize that preoperative proteinuria will be associated with an increased incidence of AKI within 48 hours after elective laparoscopic bariatric surgery. Furthermore, since there is a wide range of reported prevalence of proteinuria in the bariatric patient population, part of the value of the study will be to provide a more definitive assessment of the prevalence of proteinuria in this surgical population.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Acute Kidney Injury Obesity Proteinuria

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Patient population

Patients undergoing bariatric surgery

Urine Sample

Intervention Type OTHER

We plan to collect a urine sample during the pre-surgical visit.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Urine Sample

We plan to collect a urine sample during the pre-surgical visit.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* ≥ 18 years of age
* Subjects undergoing elective laparoscopic bariatric surgery at NYULMC, including gastric banding, sleeve gastrectomy, and Roux -en-Y gastric bypass
* Surgery scheduled at least one day after Pre Admission Testing visit

Exclusion Criteria

* Pre-existing end stage renal disease (CrCl \<30ml/min and/or need for hemodialysis)
* Medical history of systemic disease known to cause proteinuria: monoclonal gammopathy, multiple myeloma, primary amyloidosis, diabetic nephropathy, acute myeloblastic leukemia, myoglobinuria, free hemoglobinuria (i.e intravascular hemolysis)
* Known pregnancy
* Diagnosis of AKI within 6 months of surgery
* Diagnosis of cognitive dysfunction (i.e. mental retardation/developmental delay, dementia, delirium)
* Any subject who the study team feels would be unable to comply with all protocol procedures.

Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No