Multisensory Stimulation and Enriched Environments During Post-traumatic Amnesia

NCT ID: NCT02792985

Last Updated: 2016-06-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-08-31

Study Completion Date

2017-08-31

Brief Summary

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The objective of this Phase II trial is to evaluate the feasibility of this study protocol to progress to a large-scale Phase III RCT in the future. It will also determine, with limited efficacy, the effectiveness of the multisensory stimulation intervention protocol to reduce the duration of post-traumatic amnesia (PTA), improve cognition, increase independence in activities of daily living and long term quality of life of the affected person.

Participants will be randomised into either the experimental or control group. The experimental group will follow the multisensory stimulation intervention protocol, while the control group will follow the current hospital protocol.

Detailed Description

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Design: A phase II randomised controlled trial. Repeated measures of behaviour and sensory motor performance will be taken during PTA progression for all participants. The RCT involves two treatment arms and blinded assessment post-intervention at the point of PTA resolution, one month following PTA resolution, and a 6-month post-injury follow up questionnaire. The 2 treatment groups are:

1. Experimental intervention protocol: occupation-based multisensory stimulation and the use of enriched environments;
2. Control intervention protocol: standard therapy as provided by the hospital which includes re-orientation and participation in basic functional tasks.

Participants: Approximately twenty participants will be recruited from the Institut Guttmann, which is a neuro-rehabilitation hospital in Badalona, Spain.

Measures:

The evaluation tools will consist of standardised, established assessments used in brain injury rehabilitation which are detailed in the Outcome Measures section.

Procedure:

Repeated measurements of behaviour and sensory motor function corresponding to the participant's progression of PTA assessment scores will be taken. The maximum number of times a single participant will be tested during PTA is 7 times and twice again following emergence from PTA, within the first 3 days and again after 1 week. All measurements are non-invasive and provide minimal adverse risks for the participant.

Participants will be randomised into either the Experimental or Control group. Participants, their family members, and the assessor taking outcome measures at the point of PTA resolution and one-month post-resolution will be blinded to group allocation and subsequent intervention protocol. Intervention provision will occur throughout the progression of PTA with post-intervention assessment to occur within 3 days of the end of PTA, one month after coming out of PTA, and through a follow-up questionnaire to be completed by the participant and family members at 6 months post-injury. All interventions are non-invasive and do not involve any risks above those that may be incurred through participation in the standard rehabilitation process.

The Experimental group will follow an intervention protocol involving transformation of the participant´s room into a sensory stimulating enriched environment (EE) and participation in occupation-based multisensory stimulation (OBMS) during their therapy sessions with an occupational therapist. They will receive two daily 30-minute individual therapy sessions.

The control group will follow the current protocol for patients in PTA at the Institut Guttmann. This includes one 30-minute individual therapy session or one hour group therapy session with an occupational therapist and minimal changes to their room (e.g. orientation board, photos of family and friends).

Conditions

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Brain Injuries, Traumatic Confusional State Sensory Motor System Disorder Alteration of Cognitive Function

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Caregivers

Study Groups

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Multisensory stimulation protocol

The Experimental group will follow an intervention protocol.

Group Type EXPERIMENTAL

Multisensory stimulation protocol

Intervention Type BEHAVIORAL

Participation in occupation-based multisensory stimulation (e.g. personal care with aromatic soaps, varying water temperatures and textured sponges, drink preparation of different flavoured beverages) with a variety of different sensory stimuli (e.g. strong smells, different shapes and weights). The participant will receive two individual 30-minute therapy sessions with an Occupational Therapist.

An enriched environment will be set up in the participant´s bedroom. It will include items that provide a range of meaningful sensory stimuli (e.g. familiar personal objects, projection of photos and known places, familiar music). The participant is encouraged to follow a timetable including regular rest breaks through out the day in their room.

Control protocol

The Control group will follow the current protocol for patients in PTA at the Institut Guttmann.

Group Type ACTIVE_COMPARATOR

Control protocol

Intervention Type BEHAVIORAL

Retraining of basic activities of daily living or participation in table top tasks and games in an individual 30 minute session or a one hour small group session with an Occupational Therapist.

Minimal changes are made to the participant´s room (e.g. orientation board, photos of family and friends).

Interventions

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Multisensory stimulation protocol

Participation in occupation-based multisensory stimulation (e.g. personal care with aromatic soaps, varying water temperatures and textured sponges, drink preparation of different flavoured beverages) with a variety of different sensory stimuli (e.g. strong smells, different shapes and weights). The participant will receive two individual 30-minute therapy sessions with an Occupational Therapist.

An enriched environment will be set up in the participant´s bedroom. It will include items that provide a range of meaningful sensory stimuli (e.g. familiar personal objects, projection of photos and known places, familiar music). The participant is encouraged to follow a timetable including regular rest breaks through out the day in their room.

Intervention Type BEHAVIORAL

Control protocol

Retraining of basic activities of daily living or participation in table top tasks and games in an individual 30 minute session or a one hour small group session with an Occupational Therapist.

Minimal changes are made to the participant´s room (e.g. orientation board, photos of family and friends).

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* diagnosis of TBI
* within 6 months of their initial brain injury
* in PTA (Levels of Cognitive Function 4-6)
* appropriate visual and auditory function to observe the environment and hear instructions with or without assistive aids
* independent use of one upper limb

Exclusion Criteria

* a previous brain injury
* illness, diseases or alcohol or drug addiction that could affect cognitive function
* having a learning disability prior to injury
* participant is out of PTA
* visual, auditory, aphasic or motor disturbance that may interfere with the ability to complete the task or participate in the sessions
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The University of Queensland

OTHER

Sponsor Role collaborator

Institut Guttmann

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Narda Murillo, PhD

Role: PRINCIPAL_INVESTIGATOR

Institut Guttmann

Locations

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Institut Guttmann

Badalona, Barcelona, Spain

Site Status RECRUITING

Countries

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Spain

Central Contacts

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Hayley Walsh

Role: CONTACT

+34934977700 ext. 2146

Facility Contacts

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Narda Murillo, PhD

Role: primary

+34934977700 ext. 2146

Other Identifiers

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2014.205

Identifier Type: -

Identifier Source: org_study_id

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