The Relationship Between White Matter Hyperintensity With Cognition and Emotion

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-01-31

Study Completion Date

2019-12-31

Brief Summary

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White matter hyperintensity (WMH) has been found to be related with cognitive and emotional dysfunction. A presumed mechanism is that WMH disrupts the structural connectivity within a large-scale brain network, thereby impairing the brain's ability to integrate the neural processes efficiently. It is not yet clear, what the pattern of brain network disruption relates to WMH and how the brain network disruption induced by WMH has an effect on cognition and emotion performance. Using multi-model magnetic resonance imaging (MRI) techniques, we aimed to explore the mechanisms of cognitive decline and depression related with brain network dysfunction in patients with WMH, and to provide objective imaging marker for early diagnosis and prevention of WMH associated cognitive decline and depression.

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Detailed Description

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Conditions

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Aged Leukoaraiosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Control

No interventions assigned to this group

White matter hyperintensity

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

1. white matter hyperintensity visible on T2 fluid-attenuated inversion recovery images;
2. age between 35 to 80 years;
3. without stroke lesion (except lacunar infarction) on current diffusion weighted images;
4. without a history of multiple sclerosis, Alzheimer's disease, Parkinson's disease and head trauma.

Exclusion Criteria

1. white matter lesions of nonvascular origin (immunological-demyelinating, metabolic, toxic, infectious, other);
2. intracranial hemorrhage;
3. with severe head motion on magnetic resonance images

Minimum Eligible Age

35 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes