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MRI,Gene And Cognitive Performance Study of Patients With Cerebral White Matter Lesions(WMLs)

NCT ID: NCT02276976

Last Updated: 2015-12-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-03-31

Study Completion Date

2019-09-30

Brief Summary

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The purpose of this study is:1)to observe topological organization in brain structural and functional networks in cerebral white matter lesion patients and to evaluate the association between impairment of cognitive function and cerebral structural and functional networks in those patients;2)to indicate the role of genetic factors in the occurrence and prognosis of cerebral white matter lesions

Detailed Description

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100 patients with cerebral white matter lesions and 100 normal controls will be observed. All of them will receive MRI scan(T1WI,T2WI,T2flair,MRA,SWI,ASL,DTI and fMRI) and the assessment of the neuropsychological function (MMSE,Auditory verbal memory test,Trail-making test-A and -B,Symbol digit modalities test,Digit span test,Clock drawing test,HAMD) intending to analyse topological organization in brain structural and functional networks in cerebral white matter lesion patients and to evaluate the association between impairment of cognitive function and cerebral structural and functional networks in those patients.Furthermore,DNA will be extracted from the blood sample of all participates to perform High-throughput sequencing. MRI scan and neuropsychological function assessment will be performed repeatedly after 1,3 and 5 years.

Conditions

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Cerebral White Matter Lesions

Keywords

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crebral white matter lesions brain networks MRI DTI fMRI cognitive impairment gene

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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cerebral white matter lesions

patients with MRI confirmed cerebral white matter lesions

No interventions assigned to this group

healthy volunteers

healthy volunteers 1:1 matched by age,sex and education years

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* MRI diagnosis of cerebral white matter lesions Must be able to measure his(her) neuropsychologic function No severe stroke history and no physical disability Patients aged 40 to 85 Based on China's relevant laws, the patient himself agreed to participate in this study, a good compliance.Patients himself/herself must sign informed consent moreover

Exclusion Criteria

* Unable to undergo examinations due to disturbances of consciousness or medical conditions Serious complications including severe heart failure, hepatic dysfunction, renal insufficiency,or shock AD,Parkinson's disease, malignant tumor, MS and other autoimmune diseases toxic and metabolic encephalopathy cerebral white matter lesions caused by CADASIL and other confirmed monogenic disease
Minimum Eligible Age

40 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Wei Wang

OTHER

Sponsor Role lead

Responsible Party

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Wei Wang

professor

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Wei Wang, Doctor

Role: PRINCIPAL_INVESTIGATOR

Tongji Hospital

Locations

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Department of Neurology of Tongji Hospital, Huazhong University of Science and Technology

Wuhan, Hubei, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Wei Wang, Doctor

Role: CONTACT

Phone: 86-027-8366-3648

Email: [email protected]

Facility Contacts

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Wei Wang, Doctor

Role: primary

Other Identifiers

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2013BCB022

Identifier Type: -

Identifier Source: org_study_id