MEG and DTI of Neural Function and Connectivity in Traumatic Brain Injury

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

69 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-02-28

Study Completion Date

2013-02-28

Brief Summary

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The overall hypothesis is that the long-term cognitive and behavioral sequelae of traumatic brain injury (TBI) are due to selective disruption of the long association white matter tracts of the cerebral hemispheres, with resulting functional impairment of the network of cortical regions that are interconnected by these long-range association pathways. We propose that traumatic white matter injury can be measured with diffusion tensor imaging (DTI) and that the impaired cortical activation can be detected with magnetoencephalography (MEG), and that the results of these imaging examinations will correlate with neurocognitive status and functional recovery after TBI.

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Detailed Description

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Conditions

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Traumatic Brain Injury Post-concussive Symptoms

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Traumatic brain injured patients

This group consists of participants who suffered a traumatic brain injury an average of 4 months to 4 years prior to testing. Patients must not have history of prior head injury, substance abuse, psychiatric illness, or contraindications to MRI.

No interventions assigned to this group

Controls (no traumatic brain injury)

This group consists of participants who do not have a history of brain trauma. Furthermore, controls must not suffer from substance abuse, psychiatric illness, or have contraindications to the MRI.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* 18-50 years of age
* single episode of blunt traumatic brain injury
* symptoms of persistent post-concussive syndrome present an average of 4 months to 4 years since date of injury
* fluency in English (cognitive battery not available in other languages)
* capable of self-consent

Exclusion Criteria

* \< 18 years or \> 50 years of age
* pregnancy
* history of previous TBI with loss of consciousness
* alcoholism as evidenced by Audit questionnaire
* regular use of illicit drugs
* non-English fluency
* significant psychiatric history excluding mild depression or anxiety disorder any contraindication to MRI, including claustrophobia, pregnancy, any trauma or surgery which may have left ferromagnetic material in the body, ferromagnetic implants or pacemakers; and inability to lie still for 1 hour or more

Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes