Arteriovenous Plasma Multiomics in Patients With Disorders of Consciousness
NCT ID: NCT06403176
Last Updated: 2024-05-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
100 participants
OBSERVATIONAL
2022-05-01
2024-04-30
Brief Summary
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Detailed Description
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Method:The uptake and release of substances by the brain were observed by comparing arterial blood with internal jugular vein blood;The characteristics of brain metabolites were observed by comparing internal jugular vein blood with superior vena cava blood. Compared it with the peripheral plasma metabolome of two additional patient cohorts: those in-stent restenosis and non-restenosis.
Objective:By analyzing different substances, this paper briefly describes the pathological mechanism of patients with disorders of consciousness, and looks for potential prognostic biomarkers.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Minimally conscious state (MCS)
Minimally conscious state (MCS): have reproducible signs of awareness and exhibit fluctuations in consciousness
No intervention
No intervention
Vegetative state (VS)
Vegetative state (VS): can open their eyes and preserve sleep-wake cycles, but unaware of themselves and their surroundings
No intervention
No intervention
Patients with In-Stent Restenosis
In-Stent Restenosis was defined as greater than 50% within or immediately adjacent (within 5 mm) to the stent implanted that was detected by digital subtraction angiography (DSA).
No intervention
No intervention
Patients with Non-Restenosis
In-Stent Restenosis was defined as less than 50% within or immediately adjacent (within 5 mm) to the stent implanted that was detected by digital subtraction angiography (DSA).
No intervention
No intervention
Interventions
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No intervention
No intervention
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
2. There are persistent epileptic activity, inhibition or seizure inhibition patterns
3. Recent fever, abnormal liver and kidney function
4. Previous history of neurological or mental illness
5. Have a history of tumor
6. Inflammatory bowel diseases, hyperlipidemia, gastritis
18 Years
80 Years
ALL
No
Sponsors
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First Affiliated Hospital of Zhejiang University
OTHER
Responsible Party
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Locations
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The First Affiliated Hospital of Zhejiang University
Hanzhou, Zhejiang, China
Countries
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Other Identifiers
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plasma multiomics
Identifier Type: -
Identifier Source: org_study_id
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