Multiomic Analysis of Body Fluid in Acute Traumatic Brain Injury
NCT ID: NCT05778123
Last Updated: 2023-05-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
10 participants
OBSERVATIONAL
2023-04-01
2024-12-31
Brief Summary
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* Which RNA, protein and metabolites are differently expressed in lesion tissues?
* What molecular mechanism is participated in TBI? Participants will be treated by emergency operation, and their body fluid samples will be collected in emergency room and during the operation.
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Detailed Description
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Conditions
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Study Design
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OTHER
PROSPECTIVE
Study Groups
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TBI
Patients with traumatic brain injury.
Type of disease
Different types of pathogen: brain injury by trauma or hydrocephalus due to various diseases.
Control
Patients with hydrocephalus.
Type of disease
Different types of pathogen: brain injury by trauma or hydrocephalus due to various diseases.
Interventions
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Type of disease
Different types of pathogen: brain injury by trauma or hydrocephalus due to various diseases.
Eligibility Criteria
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Inclusion Criteria
2. Within 12 hours after brain injury
3. Control group is hydrocephalus
4. GCS ≥3 and ≤8
5. Closed brain injury with frontotemporal contusion
6. Need emergency intracranial hematoma evacuating or cerebrospinal fluid shunting operation
7. Patient's agents are informed and consent the research
Exclusion Criteria
2. Death within 24 hours
3. Immunosuppression state
4. Severe organ dysfunction
5. Complicated infective disease
6. Pregnant
16 Years
65 Years
ALL
No
Sponsors
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RenJi Hospital
OTHER
Responsible Party
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Junfeng Feng
Director of Brain Injury Center
Locations
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Brain Injury Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Shanghai, Shanghai Municipality, China
Countries
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Central Contacts
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Facility Contacts
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Junfeng Feng
Role: primary
Other Identifiers
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LY2023-018-B
Identifier Type: -
Identifier Source: org_study_id
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